To discover and develop novel natural compounds, active ingredients, single herbs and
combination formulas or prescriptions in traditional Chinese medicine (TCM) with …

Oxymatrine (OMT), was identified as a quinolizidine alkaloid, which was one of the major
matrine-type alkaloids extracted from Sophora medicinal plants. Growing studies revealed …

Osteoarthritis (OA) is the most common degenerative joint disease in the world. Gene
therapy based on delivering microRNAs (miRNAs) into cells has potential for the treatment …

Matrine (MT) and oxymatrine (OMT), two kinds of alkaloid components found in the roots of
Sophora species, have various pharmacological activities and are demonstrated to have …

Despite significant technological advancements in conventional therapies, cancer remains
one of the main causes of death worldwide. Although substantial progress has been made …

Abstract Kushen (Radix Sophorae Flavescentis) has a long history of use for the treatment of
tumors, inflammation and other diseases in traditional Chinese medicine. Compound …

Oxymatrine (OMT) is a major alkaloid found in radix Sophorae flavescentis extract and has
been reported to exhibit various pharmacological activities. We elucidated the detailed …

Oxymatrine (OMT) is a quinolizidine alkaloid derived from the roots of the Sophora genus
plants. It has been widely used as a treatment for chronic hepatitis infections and …

The morbidity associated with cancer has rapidly increased in recent years, and in the
previous 5 years has had a tendency to be the leading cause of fatality compared with …

To discover and develop novel natural compounds with therapeutic selectivity or that can
preferentially kill cancer cells without significant toxicity to normal cells is an important area …