In recent years, stem cell therapy has become a very promising and advanced scientific
research topic. The development of treatment methods has evoked great expectations. This …

This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

Studies in embryonic development have guided successful efforts to direct the differentiation
of human embryonic and induced pluripotent stem cells (PSCs) into specific organ cell types …

Background & Aims Human induced pluripotent stem cell (hiPSC)-derived liver modeling
systems have the potential to overcome the shortage of donors for clinical application and …

Over the years, various liver-derived in vitro model systems have been developed to enable
investigation of the potential adverse effects of chemicals and drugs. Liver tissue slices …

There exists a worldwide shortage of donor livers available for orthotropic liver
transplantation and hepatocyte transplantation therapies. In addition to their therapeutic …

Pluripotent stem cells (PSCs) hold great promise for drug discovery and regenerative
medicine owing to their ability to differentiate into any cell type in the body. After more than …

Generation of functional and vascularized organs from human induced pluripotent stem cells
(iPSCs) will facilitate our understanding of human developmental biology and disease …

Extracellular vesicles (EV s), membrane vesicles that are secreted by a variety of
mammalian cell types, have been shown to play an important role in intercellular …

Despite the tremendous hurdles presented by the complexity of the liver's structure and
function, advances in liver physiology, stem cell biology and reprogramming, and the …