Application of patient-specific computational fluid dynamics in coronary and intra-cardiac flow simulations: Challenges and opportunities

L Zhong, JM Zhang, B Su, RS Tan, JC Allen… - Frontiers in …, 2018 - frontiersin.org
The emergence of new cardiac diagnostics and therapeutics of the heart has given rise to
the challenging field of virtual design and testing of technologies in a patient-specific …

[HTML][HTML] Transport physics and biorheology in the setting of hemostasis and thrombosis

LF Brass, SL Diamond - Journal of Thrombosis and Haemostasis, 2016 - Elsevier
The biophysics of blood flow can dictate the function of molecules and cells in the
vasculature with consequent effects on hemostasis, thrombosis, embolism, and fibrinolysis …

Effect of shape of the stenosis on the hemodynamics of a stenosed coronary artery

N Freidoonimehr, R Chin, A Zander, M Arjomandi - Physics of Fluids, 2021 - pubs.aip.org
In this study, the effect of the shape of the stenosis on the flow transition in an artery is
investigated. Different shapes of the stenosis including round, oval, elongated, half-moon …

Numerical study of wall shear stress-based descriptors in the human left coronary artery

SIS Pinto, J Campos - Computer methods in biomechanics and …, 2016 - Taylor & Francis
The present work is about the application of wall shear stress descriptors–time averaged
wall shear stress (TAWSS), oscillating shear index (OSI) and relative residence time (RRT) …

Simplified models of non-invasive fractional flow reserve based on CT images

JM Zhang, L Zhong, T Luo, AM Lomarda, Y Huo, J Yap… - PloS one, 2016 - journals.plos.org
Invasive fractional flow reserve (FFR) is the gold standard to assess the functional coronary
stenosis. The non-invasive assessment of diameter stenosis (DS) using coronary computed …

Numerical modeling of hemodynamics scenarios of patient-specific coronary artery bypass grafts

F Ballarin, E Faggiano, A Manzoni, A Quarteroni… - … and modeling in …, 2017 - Springer
A fast computational framework is devised to the study of several configurations of patient-
specific coronary artery bypass grafts. This is especially useful to perform a sensitivity …

Transitional turbulent flow in a stenosed coronary artery with a physiological pulsatile flow

N Freidoonimehr, M Arjomandi… - International Journal …, 2020 - Wiley Online Library
The turbulence in the blood flow, caused by plaque deposition on the arterial wall, increases
by the combined effect of the complex plaque geometries and the pulsatile blood flow. The …

Geometrical effects in the hemodynamics of stenotic and non‐stenotic left coronary arteries—numerical and in vitro approaches

E Doutel, N Viriato, J Carneiro… - … journal for numerical …, 2019 - Wiley Online Library
Atherosclerosis is a common cardiovascular disease found in the left coronary artery (LCA),
closely linked to local hemodynamic, which, in turn, is highly influenced by the artery …

Effect of microcirculatory dysfunction on coronary hemodynamics: A pilot study based on computational fluid dynamics simulation

Y Geng, H Liu, X Wang, J Zhang, Y Gong… - Computers in Biology …, 2022 - Elsevier
Background Invasively measured fractional flow reserve (FFR) and index of microcirculatory
resistance (IMR) are gold standards for the diagnosis of coronary artery disease (CAD) and …

High precision invasive FFR, low‐cost invasive iFR, or non‐invasive CFR?: optimum assessment of coronary artery stenosis based on the patient‐specific …

F Tajeddini, MR Nikmaneshi… - International Journal …, 2020 - Wiley Online Library
The objective of this paper is to apply computational fluid dynamic (CFD) as a
complementary tool for clinical tests to not only predict the present and future status of left …