Folate plays a key role in the interactions between nutrition, fetal programming, and
epigenomics. Maternal folate status influences DNA methylation, inheritance of the agouti …

Background: First isolated as cyanocobalamin in 1948, vitamin B12 has been explored for
pain treatment almost since its discovery. With the advent of the opioid epidemic, safer …

Aliment Pharmacol Ther 2011; 34: 1173–1184 Summary Background The magnitude of
association between homocysteine metabolism and inflammatory bowel diseases (IBD) …

The intestine has direct contact with nutritional information. The mechanisms by which
particular dietary molecules affect intestinal homeostasis are not fully understood. In this …

BACKGROUND & AIMS: Folate and cobalamin are methyl donors needed for the synthesis
of methionine, which is the precursor of S-adenosylmethionine, the substrate of methylation …

Folate serves as a cofactor for one-carbon (1C) transfer reactions. These reactions are
involved in the synthesis of DNA nucleotides, the amino acid methionine, and in the …

Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are
thought to be predominant proteases and protease inhibitors involved in the pathogenesis of …

Background Methyl donor deficiency (MDD) aggravates experimental colitis in rats and
increases endoplasmic reticulum (ER) stress through decreased sirtuin 1 (SIRT1) in …

Inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC) are
common diseases of the digestive system. Vitamin deficiencies and gut microbiota dysbiosis …

Tissues of the mucosa are lined by an epithelium that provides barrier and transport
functions. It is now appreciated that inflammatory responses in inflammatory bowel diseases …