Neurodevelopmental outcomes of prenatal preeclampsia exposure

SB Gumusoglu, ASS Chilukuri, DA Santillan… - Trends in …, 2020 - cell.com
Preeclampsia is a dangerous hypertensive disorder of pregnancy with known links to
negative child health outcomes. Here, we review epidemiological and basic neuroscience …

Epigenetics of pregnancy: looking beyond the DNA code

D Zuccarello, U Sorrentino, V Brasson, L Marin… - Journal of assisted …, 2022 - Springer
Epigenetics is the branch of genetics that studies the different mechanisms that influence
gene expression without direct modification of the DNA sequence. An ever-increasing …

Maternal distress during pregnancy and the postpartum period: underlying mechanisms and child's developmental outcomes—a narrative review

L Jeličić, A Veselinović, M Ćirović, V Jakovljević… - International Journal of …, 2022 - mdpi.com
Maternal mental health may be considered a determining factor influencing fetal and child
development. An essential factor with potentially negative consequences for a child's …

Maternal prenatal stress, thyroid function and neurodevelopment of the offspring: A mini review of the literature

F Anifantaki, P Pervanidou, I Lambrinoudaki… - Frontiers in …, 2021 - frontiersin.org
Fetal brain is extremely plastic and vulnerable to environmental influences that may have
long-term impact on health and development of the offspring. Both the Hypothalamic …

Increases in maternal depressive symptoms during pregnancy and infant cortisol reactivity: mediation by placental corticotropin-releasing hormone

GR Rinne, JA Somers, IF Ramos, KM Ross… - Development and …, 2023 - cambridge.org
Background: Maternal depressive symptoms in pregnancy may affect offspring health
through prenatal programming of the hypothalamic–pituitary–adrenal (HPA) axis. The …

The brain-placental axis: Therapeutic and pharmacological relevancy to pregnancy

SK Behura, P Dhakal, AM Kelleher, A Balboula… - Pharmacological …, 2019 - Elsevier
The placenta plays a critical role in mammalian reproduction. Although it is a transient
organ, its function is indispensable to communication between the mother and fetus, and …

Stress, thyroid dysregulation, and thyroid cancer in children and adolescents: proposed impending mechanisms

A Kyriacou, V Tziaferi, M Toumba - Hormone Research in Paediatrics, 2023 - karger.com
Stress is a potential catalyst for thyroid dysregulation through cross-communication of the
hypothalamic-pituitary-adrenal and hypothalamic-pituitary-thyroid (HPT) axes. Stress and …

Role of the serotonin receptor 7 in brain plasticity: From development to disease

M Crispino, F Volpicelli, C Perrone-Capano - International journal of …, 2020 - mdpi.com
Our knowledge on the plastic functions of the serotonin (5-HT) receptor subtype 7 (5-HT7R)
in the brain physiology and pathology have advanced considerably in recent years. A wealth …

Molecular pathways in placental-fetal development and disruption

JJ Adibi, Y Zhao, H Koistinen, RT Mitchell… - Molecular and cellular …, 2024 - Elsevier
The first trimester of pregnancy ranks high in priority when minimizing harmful exposures,
given the wide-ranging types of organogenesis occurring between 4-and 12-weeks' …

Obesity in pregnancy—Long‐term effects on offspring hypothalamic‐pituitary‐adrenal axis and associations with placental cortisol metabolism: A systematic review

T Volqvartz, HHB Andersen… - European Journal of …, 2023 - Wiley Online Library
Obesity, affecting one in three pregnant women worldwide, is not only a major obstetric risk
factor. The resulting low‐grade inflammation may have a long‐term impact on the offspring's …