[HTML][HTML] Drug-targeting methodologies with applications: A review

C Kleinstreuer, Y Feng, E Childress - World Journal of Clinical …, 2014 - ncbi.nlm.nih.gov
Targeted drug delivery to solid tumors is a very active research area, focusing mainly on
improved drug formulation and associated best delivery methods/devices. Drug-targeting …

In Silico Methods for Development of Generic Drug–Device Combination Orally Inhaled Drug Products

RL Walenga, AH Babiskin… - CPT: pharmacometrics & …, 2019 - Wiley Online Library
The development of generic, single‐entity, drug–device combination products for orally
inhaled drug products is challenging in part because of the complex nature of device design …

Flow structure and particle deposition analyses for optimization of a pressurized metered dose inhaler (pMDI) in a model of tracheobronchial airway

K Ahookhosh, M Saidi, M Mohammadpourfard… - European Journal of …, 2021 - Elsevier
Inhalation therapy plays an important role in management or treatment of respiratory
diseases such asthma and chronic obstructive pulmonary diseases (COPDs). For decades …

Evaluation of aerosol drug delivery options during adult mechanical ventilation in the COVID-19 era

PJ Naughton, M Joyce, M Mac Giolla Eain, A O'Sullivan… - Pharmaceutics, 2021 - mdpi.com
Drug delivery devices used for aerosol therapy during mechanical ventilation to ease the
symptoms of respiratory diseases provide beneficial treatment but can also pose challenges …

Understanding pressurized metered dose inhaler performance

JW Ivey, R Vehring, WH Finlay - Expert opinion on drug delivery, 2015 - Taylor & Francis
Introduction: Deepening the current understanding of the factors governing the performance
of the pressurized metered dose inhaler (pMDI) has the potential to benefit patients by …

Effect of pressurized metered dose inhaler spray characteristics and particle size distribution on drug delivery efficiency

M Yousefi, K Inthavong, J Tu - Journal of aerosol medicine and …, 2017 - liebertpub.com
Background: A key issue in pulmonary drug delivery is improvement of the delivery device
for effective and targeted treatment. Pressurized metered dose inhalers (pMDIs) are the most …

External and near-nozzle spray characteristics of a continuous spray atomized from a nasal spray device

K Inthavong, W Yang, MC Fung… - Aerosol Science and …, 2012 - Taylor & Francis
Computational fluid dynamics (CFD) simulations of nasal drug delivery often neglect the
initial spray particle conditions (eg, particle velocity) and instead introduce particles …

Evaluation of metered dose inhaler spray velocities using Phase Doppler Anemometry (PDA)

X Liu, WH Doub, C Guo - International journal of pharmaceutics, 2012 - Elsevier
Droplet velocity is an important parameter which can significantly influence inhalation drug
delivery performance. Together with the droplet size, this parameter determines the …

High-speed laser image analysis of plume angles for pressurised metered dose inhalers: the effect of nozzle geometry

Y Chen, PM Young, S Murphy, DF Fletcher, E Long… - AAPS …, 2017 - Springer
The aim of this study is to investigate aerosol plume geometries of pressurised metered
dose inhalers (pMDIs) using a high-speed laser image system with different actuator nozzle …

The effect of ethanol on the formation and physico-chemical properties of particles generated from budesonide solution-based pressurized metered-dose inhalers

B Zhu, D Traini, HK Chan, PM Young - Drug development and …, 2013 - Taylor & Francis
The aerosol performance of budesonide solution-based pressurized metered-dose inhalers
(HFA 134a), with various amounts of ethanol (5–30%, w/w) as co-solvents, was evaluated …