The limb bud is of paradigmatic value to understanding vertebrate organogenesis. Recent
genetic analysis in mice has revealed the existence of a largely self-regulatory limb bud …

Wnt signaling is one of a handful of powerful signaling pathways that play crucial roles in the
animal life by controlling the genetic programs of embryonic development and adult …

Fibroblast growth factors (FGFs) are key regulators of several developmental processes in
which cell fate and differentiation to various tissue lineages are determined. The importance …

Multipotential adult mesenchymal stem cells (MSCs) are able to differentiate along several
known lineages, and lineage commitment is tightly regulated through specific cellular …

Abstract Dickkopf1 (Dkk1) is a secreted protein that acts as a Wnt inhibitor and, together with
BMP inhibitors, is able to induce the formation of ectopic heads in Xenopus. Here, we show …

This outstanding work is the only modern book devoted to the chick embryo and has been
an essential resource for geneticists, molecular and developmental biologists, and other life …

The limb is a commonly used model system for developmental biology. Given the need for
precise control of complex signalling pathways to achieve proper patterning, the limb is also …

A unique mutation in LRP5 is associated with high bone mass in man. Transgenic mice
expressing this LRP5 mutation have a similar phenotype with high bone mass and …

▪ Abstract Ovulation is a complex process that is initiated by the lutenizing hormone surge
and is controlled by the temporal and spatial expression of specific genes. This review …

The development of tissues and organs in embryos is controlled by an interplay of several
signaling pathways that cross-talk to provide positional information and induce cell fate …