Levamisole in children with idiopathic nephrotic syndrome: clinical efficacy and pathophysiological aspects

AK Mühlig, JY Lee, MJ Kemper, A Kronbichler… - Journal of Clinical …, 2019 - mdpi.com
Steroid sensitive nephrotic syndrome is one of the most common pediatric glomerular
diseases. Unfortunately, it follows a relapsing and remitting course in the majority of cases …

Optimizing the corticosteroid dose in steroid-sensitive nephrotic syndrome

MT Christian, AP Maxted - Pediatric Nephrology, 2022 - Springer
The use of corticosteroids in the treatment of steroid-sensitive nephrotic (SSNS) syndrome in
children has evolved surprisingly slowly since the ISKDC consensus over 50 years ago …

[HTML][HTML] A randomized clinical trial indicates that levamisole increases the time to relapse in children with steroid-sensitive idiopathic nephrotic syndrome

MP Gruppen, AH Bouts, MC Jansen-van der Weide… - Kidney international, 2018 - Elsevier
Levamisole has been considered the least toxic and least expensive steroid-sparing drug for
preventing relapses of steroid-sensitive idiopathic nephrotic syndrome (SSINS). However …

[HTML][HTML] Efficacy and safety of mycophenolate mofetil versus levamisole in frequently relapsing nephrotic syndrome: an open-label randomized controlled trial

A Sinha, M Puraswani, M Kalaivani, P Goyal, P Hari… - Kidney international, 2019 - Elsevier
Both levamisole and mycophenolate mofetil (MMF) prevent relapses in patients with
frequently relapsing nephrotic syndrome; however, their efficacy has not been compared …

[PDF][PDF] Levamisole in steroid-sensitive nephrotic syndrome: usefulness in adult patients and laboratory insights into mechanisms of action via direct action on the …

L Jiang, I Dasgupta, JA Hurcombe, HF Colyer… - Clinical Science, 2015 - Citeseer
Minimal change nephropathy (MCN) is the third most common cause of primary nephrotic
syndrome in adults. Most patients with MCN respond to corticosteroid therapy, but relapse is …

Prevention of relapses with levamisole as adjuvant therapy in children with a first episode of idiopathic nephrotic syndrome: study protocol for a double blind …

F Veltkamp, DH Khan, C Reefman, S Veissi… - BMJ open, 2019 - bmjopen.bmj.com
Introduction Idiopathic nephrotic syndrome (INS) is characterised by a high relapse rate up
to 80% after initial response to standard therapy with corticosteroids. Steroid toxicity is …

Levamisole therapy in children with frequently relapsing and steroid-dependent nephrotic syndrome: a single-center experience

E Kuźma-Mroczkowska, P Skrzypczyk… - … European Journal of …, 2016 - termedia.pl
Results: The duration of nephrotic syndrome was 3.4±2.9 years, and the number of relapses
before levamisole treatment was 6.0±3.4. The dose of prednisone on initiation of levamisole …

Efficacy and safety of levamisole in childhood nephrotic syndrome: A meta-analysis

GC Bhatt, B Patel, RR Das, S Malik… - Indian Journal of …, 2023 - journals.lww.com
Present evidence regarding the efficacy and safety of levamisole in childhood nephrotic
syndrome (NS), particularly the steroid-sensitive NS (SSNS), is limited. We searched …

[HTML][HTML] Efficacy of Levamisole in children with frequent relapsing and steroid dependent nephrotic syndrome at tertiary care Center-Karachi

KN Moorani, AM Zubair, NR Veerwani… - Pakistan Journal of …, 2020 - ncbi.nlm.nih.gov
Objectives: To determine the effectiveness of levamisole in maintaining remission of
proteinuria in children with frequent relapsing and steroid dependent nephrotic syndrome …

Immunosuppressive therapy in children with primary nephrotic syndrome: single center experience, Karachi, Pakistan

KN Moorani, HM Hotchandani, AM Zubair, NC Lohana… - BMC nephrology, 2019 - Springer
Background Majority of children with nephrotic syndrome are steroid sensitive, but treatment
of difficult to treat nephrotic (frequent relapsing, steroid dependent and steroid resistant) …