Astrocyte function from information processing to cognition and cognitive impairment

M Santello, N Toni, A Volterra - Nature neuroscience, 2019 - nature.com
Astrocytes serve important roles that affect recruitment and function of neurons at the local
and network levels. Here we review the contributions of astrocyte signaling to synaptic …

Multi-lineage human iPSC-derived platforms for disease modeling and drug discovery

A Sharma, S Sances, MJ Workman, CN Svendsen - Cell stem cell, 2020 - cell.com
Human induced pluripotent stem cells (hiPSCs) provide a powerful platform for disease
modeling and have unlocked new possibilities for understanding the mechanisms governing …

[HTML][HTML] Astrocytic modulation of neuronal excitability through K+ spatial buffering

A Bellot-Saez, O Kékesi, JW Morley… - … & Biobehavioral Reviews, 2017 - Elsevier
The human brain contains two major cell populations, neurons and glia. While neurons are
electrically excitable and capable of discharging short voltage pulses known as action …

Neuron-glia networks: integral gear of brain function

G Perea, M Sur, A Araque - Frontiers in cellular neuroscience, 2014 - frontiersin.org
Astrocytes, the most abundant glial cell in the brain, play critical roles in metabolic and
homeostatic functions of the Nervous System; however, their participation in coding …

[PDF][PDF] A physical view of computational neurodynamics

J Ma, Z Yang, L Yang, J Tang - Journal of Zhejiang University …, 2019 - drive.google.com
The nervous system is made of a large number of neurons. Time-varying balance between
excitatory and inhibitory neurons is important to activate appropriate modes of electrical …

The role of astrocytes in the regulation of synaptic plasticity and memory formation

Y Ota, AT Zanetti, RM Hallock - Neural plasticity, 2013 - Wiley Online Library
Astrocytes regulate synaptic transmission and play a role in the formation of new memories,
long‐term potentiation (LTP), and functional synaptic plasticity. Specifically, astroglial …

[HTML][HTML] Human iPSC-derived neuronal models for in vitro neurotoxicity assessment

AM Tukker, FMJ Wijnolts, A de Groot, RHS Westerink - Neurotoxicology, 2018 - Elsevier
Neurotoxicity testing still relies on ethically debated, expensive and time consuming in vivo
experiments, which are unsuitable for high-throughput toxicity screening. There is thus a …

Purinergic signaling mediates neuroglial interactions to modulate sighs

LJ Severs, NE Bush, LA Quina… - Nature …, 2023 - nature.com
Sighs prevent the collapse of alveoli in the lungs, initiate arousal under hypoxic conditions,
and are an expression of sadness and relief. Sighs are periodically superimposed on …

Controlling synchronization of gamma oscillations by astrocytic modulation in a model hippocampal neural network

S Makovkin, E Kozinov, M Ivanchenko, S Gordleeva - Scientific reports, 2022 - nature.com
Recent in vitro and in vivo experiments demonstrate that astrocytes participate in the
maintenance of cortical gamma oscillations and recognition memory. However, the …

The impact of neuroimmune alterations in autism spectrum disorder

C Gottfried, V Bambini-Junior, F Francis… - Frontiers in …, 2015 - frontiersin.org
Autism spectrum disorder (ASD) involves a complex interplay of both genetic and
environmental risk factors, with immune alterations and synaptic connection deficiency in …