[HTML][HTML] The consequences of recurrent genetic and epigenetic variants in human pluripotent stem cells
It is well established that human pluripotent stem cells (hPSCs) can acquire genetic and
epigenetic changes during culture in vitro. Given the increasing use of hPSCs in research …
epigenetic changes during culture in vitro. Given the increasing use of hPSCs in research …
Tumorigenicity as a clinical hurdle for pluripotent stem cell therapies
Human pluripotent stem cells (PSCs) are a leading candidate for cell-based therapies
because of their capacity for unlimited self renewal and pluripotent differentiation. These …
because of their capacity for unlimited self renewal and pluripotent differentiation. These …
A reference human induced pluripotent stem cell line for large-scale collaborative studies
CB Pantazis, A Yang, E Lara, JA McDonough… - Cell stem cell, 2022 - cell.com
Human induced pluripotent stem cell (iPSC) lines are a powerful tool for studying
development and disease, but the considerable phenotypic variation between lines makes it …
development and disease, but the considerable phenotypic variation between lines makes it …
The landscape of somatic copy-number alteration across human cancers
R Beroukhim, CH Mermel, D Porter, G Wei… - Nature, 2010 - nature.com
A powerful way to discover key genes with causal roles in oncogenesis is to identify
genomic regions that undergo frequent alteration in human cancers. Here we present high …
genomic regions that undergo frequent alteration in human cancers. Here we present high …
Combinatorial analysis of developmental cues efficiently converts human pluripotent stem cells into multiple neuronal subtypes
Y Maury, J Côme, RA Piskorowski… - Nature …, 2015 - nature.com
Abstract Specification of cell identity during development depends on exposure of cells to
sequences of extrinsic cues delivered at precise times and concentrations. Identification of …
sequences of extrinsic cues delivered at precise times and concentrations. Identification of …
The tumorigenicity of human embryonic and induced pluripotent stem cells
U Ben-David, N Benvenisty - Nature Reviews Cancer, 2011 - nature.com
The unique abilities of human pluripotent stem cells to self-renew and to differentiate into
cells of the three germ layers make them an invaluable tool for the future of regenerative …
cells of the three germ layers make them an invaluable tool for the future of regenerative …
Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells
Human induced pluripotent stem cells (iPSCs) represent a unique opportunity for
regenerative medicine because they offer the prospect of generating unlimited quantities of …
regenerative medicine because they offer the prospect of generating unlimited quantities of …
[HTML][HTML] Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture
Genomic stability is critical for the clinical use of human embryonic and induced pluripotent
stem cells. We performed high-resolution SNP (single-nucleotide polymorphism) analysis on …
stem cells. We performed high-resolution SNP (single-nucleotide polymorphism) analysis on …
Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage.
K Amps, PW Andrews, G Anyfantis… - Nature …, 2011 - search.ebscohost.com
Abstract The International Stem Cell Initiative analyzed 125 human embryonic stem (ES) cell
lines and 11 induced pluripotent stem (iPS) cell lines, from 38 laboratories worldwide, for …
lines and 11 induced pluripotent stem (iPS) cell lines, from 38 laboratories worldwide, for …
Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells
In embryonic stem cell (ESC) lines generated from human embryos determined through
preimplantation genetic diagnosis to carry the fragile X mutation, the FMR1 gene is …
preimplantation genetic diagnosis to carry the fragile X mutation, the FMR1 gene is …