Complex chromosome rearrangements (CCRs) are currently defined as structural genome
variations that involve more than 2 chromosome breaks and result in exchanges of …

Abstract Georges Gilles de la Tourette, in describing the syndrome that now bears his name,
observed that the condition aggregated within families. Over the last three decades …

Population-based studies to identify disease-associated risk alleles typically require
samples from a large number of individuals. Here, we report a human-induced pluripotent …

Studies of rare genetic variation have identified molecular pathways conferring risk for
developmental neuropsychiatric disorders. To date, no published whole-exome sequencing …

Background: Recent studies report an important—and previously underestimated—role of
rare variation in risk of obsessive-compulsive disorder (OCD) and chronic tic disorders …

The mammalian brain is a complex organ composed of many specialized cells, harboring
sets of both common, widely distributed, as well as specialized and discretely localized …

Background Autism spectrum disorder (ASD) is often accompanied by intellectual disability
(ID). Despite extensive studies, however, the genetic basis for this comorbidity is still not …

Tourette's Syndrome (TS) is a complex disorder characterized by repetitive, sudden, and
involuntary movements or vocalizations, called tics. Tics usually appear in childhood, and …

Chromosomal aberrations include translocations, deletions, duplications, inversions,
aneuploidies and complex rearrangements. They underlie genetic disease in roughly 15 …

Tourette disorder is a developmental neuropsychiatric condition characterized by vocal and
motor tics that can range in severity from mild to disabling. It represents one end of a …