Development of a polysaccharide-based hydrogel drug delivery system (DDS): An update

J Pushpamalar, P Meganathan, HL Tan, NA Dahlan… - Gels, 2021 - mdpi.com
Delivering a drug to the target site with minimal-to-no off-target cytotoxicity is the major
determinant for the success of disease therapy. While the therapeutic efficacy and …

Nanogels as target drug delivery systems in cancer therapy: A review of the last decade

AA Attama, PO Nnamani, OB Onokala… - Frontiers in …, 2022 - frontiersin.org
Cancer is an important cause of morbidity and mortality worldwide, irrespective of the level
of human development. Globally, it was estimated that there were 19.3 million new cases of …

Bioinert, stealth or interactive: how surface chemistry of nanocarriers determines their fate in vivo

JD Friedl, V Nele, G De Rosa… - Advanced functional …, 2021 - Wiley Online Library
Nanocarriers (NCs) have emerged as powerful tools to improve drug solubility, to promote
drug transport across membranes, to protect their payload from premature degradation, and …

Translating therapeutic microgels into clinical applications

Y Kittel, AJC Kuehne… - Advanced Healthcare …, 2022 - Wiley Online Library
Microgels are crosslinked, water‐swollen networks with a 10 nm to 100 µm diameter and
can be modified chemically or biologically to render them biocompatible for advanced …

Structural determinants of stimuli-responsiveness in amphiphilic macromolecular nano-assemblies

H Liu, HH Lu, Y Alp, R Wu, S Thayumanavan - Progress in Polymer …, 2024 - Elsevier
Stimuli-responsive nano-assemblies from amphiphilic macromolecules could undergo
controlled structural transformations and generate diverse macroscopic phenomenon under …

Targeted protein delivery based on stimuli‐triggered nanomedicine

J Liu, Y Zhou, Q Lyu, X Yao, W Wang - Exploration, 2024 - Wiley Online Library
Protein‐based drugs have shown unique advantages to treat various diseases in recent
years. However, most protein therapeutics in clinical use are limited to extracellular targets …

Bioresponsive nanogels for protein delivery

X Xu, S Shen, R Mo - View, 2022 - Wiley Online Library
Protein drugs have attracted more attentions due to their high specificity and efficacy.
However, the poor stability, plasma degradation, inferior cell membrane permeability, and …

“Smart” polymer nanogels as pharmaceutical carriers: a versatile platform for programmed delivery and diagnostics

NK Preman, S Jain, RP Johnson - ACS omega, 2021 - ACS Publications
“Smart” polymeric nanoformulations are evolving as a promising therapeutic, diagnostic
paradigm. The polymeric nanovehicles demonstrated excellent capability to encapsulate …

Development of polymer-assisted nanoparticles and nanogels for cancer therapy: An update

BNHM Neerooa, LT Ooi, K Shameli, NA Dahlan… - Gels, 2021 - mdpi.com
With cancer remaining as one of the main causes of deaths worldwide, many studies are
undergoing the effort to look for a novel and potent anticancer drug. Nanoparticles (NPs) are …

Enzyme-triggered-and tumor-targeted delivery with tunable, methacrylated poly (ethylene glycols) and hyaluronic acid hybrid nanogels

W Liwinska, E Waleka-Bagiel, Z Stojek, M Karbarz… - Drug Delivery, 2022 - Taylor & Francis
Enzyme-responsive polymeric-based nanostructures are potential candidates for serving as
key materials in targeted drug delivery carriers. However, the major risk in their prolonged …