Anti-HCV, nucleotide inhibitors, repurposing against COVID-19
AA Elfiky - Life sciences, 2020 - Elsevier
Aims A newly emerged Human Coronavirus (HCoV) is reported two months ago in Wuhan,
China (COVID-19). Until today> 2700 deaths from the 80,000 confirmed cases reported …
China (COVID-19). Until today> 2700 deaths from the 80,000 confirmed cases reported …
[HTML][HTML] Hepatitis C virus NS5A inhibitors and drug resistance mutations
S Nakamoto, T Kanda, S Wu, H Shirasawa… - World journal of …, 2014 - ncbi.nlm.nih.gov
Some direct-acting antiviral agents for hepatitis C virus (HCV), such as telaprevir and
boceprevir have been available since 2011. It was reported that HCV NS5A is associated …
boceprevir have been available since 2011. It was reported that HCV NS5A is associated …
Analysis of SARS-CoV-2 RNA-dependent RNA polymerase as a potential therapeutic drug target using a computational approach
Abstract Background The Severe acute respiratory syndrome-related coronavirus 2 (SARS-
CoV-2) outbreak originating in Wuhan, China, has raised global health concerns and the …
CoV-2) outbreak originating in Wuhan, China, has raised global health concerns and the …
Approaches to hepatitis C treatment and cure using NS5A inhibitors
JJ Kohler, JH Nettles, F Amblard… - Infection and drug …, 2014 - Taylor & Francis
Recent progress in the understanding of hepatitis C virus (HCV) biology and the availability
of in vitro models to study its replication have facilitated the development of direct-acting …
of in vitro models to study its replication have facilitated the development of direct-acting …
Repurposing therapeutics for COVID-19: Rapid prediction of commercially available drugs through machine learning and docking
Background The outbreak of the novel coronavirus disease COVID-19, caused by the SARS-
CoV-2 virus has spread rapidly around the globe during the past 3 months. As the virus …
CoV-2 virus has spread rapidly around the globe during the past 3 months. As the virus …
Novel guanosine derivatives against MERS CoV polymerase: An in silico perspective
Abstract The Middle East Respiratory Syndrome Coronavirus (MERS CoV), also termed
camel flu, is a new viral infection that first reported in the year 2012 in the Middle East region …
camel flu, is a new viral infection that first reported in the year 2012 in the Middle East region …
Quantitative structure‐activity relationship and molecular docking revealed a potency of anti‐hepatitis C virus drugs against human corona viruses
AA Elfiky, SM Mahdy… - Journal of medical …, 2017 - Wiley Online Library
A number of human coronaviruses (HCoVs) were reported in the last and present centuries.
Some outbreaks of which (eg, SARS and MERS CoVs) caused the mortality of hundreds of …
Some outbreaks of which (eg, SARS and MERS CoVs) caused the mortality of hundreds of …
The small molecules AZD0530 and dasatinib inhibit dengue virus RNA replication via Fyn kinase
M de Wispelaere, AJ LaCroix, PL Yang - Journal of virology, 2013 - Am Soc Microbiol
In this study, we characterized the antiviral mechanism of action of AZD0530 and dasatinib,
two pharmacological inhibitors of host kinases, that also inhibit dengue virus (DV) infection …
two pharmacological inhibitors of host kinases, that also inhibit dengue virus (DV) infection …
Remdesivir and ledipasvir among the FDA-approved antiviral drugs have potential to inhibit SARS-CoV-2 replication
The rapid spread of the virus, the surge in the number of deaths, and the unavailability of
specific SARS-CoV-2 drugs thus far necessitate the identification of drugs with anti-COVID …
specific SARS-CoV-2 drugs thus far necessitate the identification of drugs with anti-COVID …
Molecular dynamics and docking reveal the potency of novel GTP derivatives against RNA dependent RNA polymerase of genotype 4a HCV
Abstract Aim To work on Hepatitis C Virus (HCV), one of the major causes of liver cirrhosis
and hepatocellular carcinoma, polymerase of genotype 4a that have no solved structures …
and hepatocellular carcinoma, polymerase of genotype 4a that have no solved structures …