Vascular endothelial growth factor (VEGF) was initially characterized as a potent angiogenic
factor based on its activity on the vascular system. However, it is now well established that …

Vascular endothelial growth factor (VEGF) was discovered by its angiogenic activity.
However, during evolution, it appeared earlier as a neurotrophic factor required for the …

VEGF was initially discovered due to its angiogenic activity and therefore named “vascular
endothelial growth factor.” However, its more recently discovered neurotrophic activity may …

Abstract Amyotrophic Lateral Sclerosis (ALS) involves protracted pre-symptomatic periods of
abnormal motor neuron (MN) excitability occurring in parallel with central and peripheral …

Interventions that preserve motor neurons or restore functional motor neuroplasticity may
extend longevity in amyotrophic lateral sclerosis (ALS). Delivery of neurotrophins may …

Vascular endothelial growth factor (VEGF), also known as VEGF-A, was discovered due to
its vasculogenic and angiogenic activity, but a neuroprotective role for VEGF was later …

The most evident phenotype of degenerative motoneuron disease is the loss of motor
function which accompanies motoneuron death. In both amyotrophic lateral sclerosis (ALS) …

Amyotrophic lateral sclerosis (ALS) is a rare neuromuscular disease characterized by
severe muscle weakness mainly due to degeneration and death of motor neurons. A …

Vascular endothelial growth factor (VEGF) was initially characterized by its activity on the
vascular system. However, there is growing evidence indicating that VEGF also acts as a …

Motoneurons of the oculomotor system show lesser vulnerability to neurodegeneration
compared to other cranial motoneurons, as seen in amyotrophic lateral sclerosis (ALS). The …