With cardiovascular disease being the leading cause of morbidity and mortality worldwide,
effective and cost-efficient therapies to reduce cardiovascular risk are highly needed. Lipids …

Mammalian genomes encode genes for more than 30 phospholipase A2s (PLA2s) or
related enzymes, which are subdivided into several classes including low-molecular-weight …

Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane
glycerophospholipids to liberate arachidonic acid (AA), a precursor of eicosanoids including …

Decorin, a prototype small leucine-rich proteoglycan, regulates a vast array of cellular
processes including collagen fibrillogenesis, wound repair, angiostasis, tumor growth, and …

Østerud, Bjarne, and Eirik Bjørklid. Role of Monocytes in Atherogenesis. Physiol Rev 83:
1069-1112, 2003; 10.1152/physrev. 00005.2003.—This review focuses on the role of …

Secreted phospholipases A2 (sPLA2s) form a large family of structurally related enzymes
which are widespread in nature. Snake venoms are known for decades to contain a …

The deposition of cholesterol ester within foam cells of the artery wall is fundamental to the
pathogenesis of atherosclerosis. Modifications of low density lipoprotein (LDL), such as …

Initiation of atherosclerosis is characterized by accumulation of aggregates of small lipid
droplets and vesicles in the extracellular matrix of the arterial intima. The droplets and …

The causes of arterial calcification are beginning to be elucidated. Macrophages, mast cells,
and smooth muscle cells are the primary cells implicated in this process. The roles of a …

Cardiovascular diseases are the leading cause of global deaths, and many risk factors
contribute to their pathogenesis. In this context, prostanoids, which derive from arachidonic …