Lysine-specific demethylase 1A (LSD1, also named KDM1A) is a demethylase that can
remove methyl groups from histones H3K4me1/2 and H3K9me1/2. It is aberrantly expressed …

The use of androgen deprivation therapy and second line anti-androgens in prostate cancer
has led to the emergence of tumors employing multiple androgen receptor (AR)-dependent …

Keratin 6A (KRT6A) belongs to the keratin protein family which is a critical component of
cytoskeleton in mammalian cells. Although KRT6A upregulation in non-small cell lung …

Background CC‐90011 is an oral, potent, selective, reversible inhibitor of lysine‐specific
demethylase 1 (LSD1) that was well tolerated, with encouraging activity in patients who had …

Epigenetics has emerged as a prime focus area in the field of cancer research. Lysine-
specific demethylase 1A (LSD1), the first discovered histone demethylase, is mainly …

Neuroendocrine prostate cancer (NEPC) is the most virulent form of prostate cancer.
Importantly, our recent work examining metastatic biopsy samples demonstrates NEPC is …

Objective (s): Lysine-specific demethylase1 (LSD1), an important class of histone
demethylases, plays a crucial role in regulation of mammalian biology. The up-regulated …

LSD1 plays a pivotal role in numerous biological functions. The overexpression of LSD1 is
reported to be associated with different malignancies. Over the last decade, LSD1 has …

Introducción: El cáncer de pulmón de células pequeñas (SCLC, por sus siglas en inglés) se
caracteriza por una expectativa de vida desalentadora y una limitación en las opciones de …

Abstract Lysine-specific demethylase 1 (LSD1 or KDM1A) is overexpressed in numerous
cancers and is emerging as a critical mediator of tumor progression. Though well …