Advances and challenges in paracoccidioidomycosis serology caused by Paracoccidioides species complex: an update

JF da Silva, HC de Oliveira, CM Marcos… - … and infectious disease, 2016 - Elsevier
Understanding the possible methodologies for the rapid and inexpensive identification of
fungal infections is essential for disease diagnosis, but there are some limitations. To help …

Newer patents in antimycotic therapy

SK Shahid - Pharmaceutical Patent Analyst, 2016 - Taylor & Francis
There has been a global upsurge in fungal infections due to rise in immunodeficiencies,
debilitation and situations of violated anatomical barriers. The available antifungal repertoire …

Inhibition of PbGP43 Expression May Suggest that gp43 is a Virulence Factor in Paracoccidioides brasiliensis

I Torres, O Hernandez, D Tamayo, JF Munoz… - PloS one, 2013 - journals.plos.org
Glycoprotein gp43 is an immunodominant diagnostic antigen for paracoccidioidomycosis
caused by Paracoccidioides brasiliensis. It is abundantly secreted in isolates such as …

Therapeutic Administration of Recombinant Paracoccin Confers Protection against Paracoccidioides brasiliensis Infection: Involvement of TLRs

ACP Alegre-Maller, FC Mendonça… - PLoS neglected …, 2014 - journals.plos.org
Background Paracoccin (PCN) is an N-acetylglucosamine-binding lectin from the human
pathogenic fungus Paracoccidioides brasiliensis. Recombinant PCN (rPCN) induces a T …

Nanoformulated CHO-rPb27 vaccine enhances immunity and controls infection, mitigating lung inflammation and dysfunction during experimental …

EA Morais, EM do Nascimento Martins… - International Journal of …, 2024 - Elsevier
Paracoccidioidomycosis (PCM) is a systemic mycosis caused by the dimorphic fungus within
the genus Paracoccidioides, particularly Paracoccidioides brasiliensis. The traditional …

New advances in the development of a vaccine against paracoccidioidomycosis

LR Travassos, CP Taborda - Frontiers in Microbiology, 2012 - frontiersin.org
Paracoccidioidomycosis (PCM) is an endemic Latin American mycosis caused by
Paracoccidioides brasiliensis and also by the recently described P. lutzii. The systemic …

Impact of Paracoccin Gene Silencing on Paracoccidioides brasiliensis Virulence

FF Fernandes, AF Oliveira, TN Landgraf, C Cunha… - MBio, 2017 - Am Soc Microbiol
Among the endemic deep mycoses in Latin America, paracoccidioidomycosis (PCM),
caused by thermodimorphic fungi of the Paracoccidioides genus, is a major cause of …

Paracoccidioides brasiliensis PbP27 gene: knockdown procedures and functional characterization

I Torres, O Hernandez, D Tamayo… - FEMS Yeast …, 2014 - academic.oup.com
Paracoccidioides brasiliensis PbP27 gene encodes a protein localized in both the fungal
cytoplasm and cell wall. The parasitic infectious form produces this protein preferentially with …

Real time polymerase chain reaction (rt-PCR): a new patent to diagnostic purposes for paracoccidioidomycosis

F Rocha-Silva, L I. Gomes… - Recent Patents on …, 2016 - benthamdirect.com
Background: Paracoccidioidomycosis (PCM) is a systemic mycosis caused by dimorphic
fungi Paracoccidioides brasiliensis and Paracoccidioides lutzii. It is prevalent in Latin …

Identification and immunogenic potential of glycosylphosphatidylinositol-anchored proteins in Paracoccidioides brasiliensis

RA Gonçales, IG Portis, TF Dos Reis… - Frontiers in Fungal …, 2023 - frontiersin.org
In fungal pathogens the cell wall plays an important role in host-pathogen interactions
because its molecular components (eg, polysaccharides and proteins) may trigger immune …