▪ Abstract Comparative modeling predicts the three-dimensional structure of a given protein
sequence (target) based primarily on its alignment to one or more proteins of known …

Type II topoisomerases regulate DNA topology by making a double-stranded break in one
DNA duplex, transporting another DNA segment through this break and then resealing it …

How large is the volume of sequence space that is compatible with a given protein
structure? Starting from random sequences, low free energy sequences were generated for …

As in all scientific measurements, the parameters that result from a macromolecular structure
determination by X-ray crystallography (eg atomic coordinates and B factors) will have …

The number of macromolecular structures deposited in the Protein Data Bank now exceeds
45 000, with the vast majority determined using crystallographic methods. Thousands of …

The second edition of Structure in Protein Chemistry showcases the latest developments
and innovations in the field of protein structure analysis and prediction. The book begins by …

The accurate determination of a large number of protein structures by X-ray crystallography
makes it possible to conduct a reliable statistical analysis of the distribution of the main …

An abundant, widely dispersed, extracellular sequence repeat that contains a consensus
YWTD motif is shown here to occur in groups of six contiguous repeats. Thirteen lines of …

The growing number of protein structures solved at atomic resolution holds the promise of
further improvements in geometry-based validation parameters. Additionally, the estimated …

We present a suite of programs, named CING for Common Interface for NMR Structure
Generation that provides for a residue-based, integrated validation of the structural NMR …