Metals are essential for life, and they play a central role in the struggle between infecting
microbes and their hosts. In fact, an important aspect of microbial pathogenesis is the …

Iron is the most abundant transition metal in the human body and its bioavailability is
stringently controlled. In particular, iron is tightly bound to host proteins such as transferrin to …

To maintain iron homeostasis, fungi have to balance iron acquisition, storage, and utilization
to ensure sufficient supply and to avoid toxic excess of this essential trace element. As …

Accessory genes are variably present among members of a species and are a reservoir of
adaptive functions. In bacteria, differences in gene distributions among individuals largely …

Iron is an essential but, in excess, toxic nutrient. Therefore, fungi evolved fine-tuned
mechanisms for uptake and storage of iron, such as the production of siderophores (low …

The devastating infections that fungal pathogens cause in humans are underappreciated
relative to viral, bacterial and parasitic diseases. In recent years, the contributions to …

Iron is a necessary element for nearly all forms of life, and the ability to acquire this trace
nutrient has been identified as a key virulence factor for the establishment of infection by …

Drug resistance in fungal pathogens is of incredible importance to global health, yet the
mechanisms of drug action remain only loosely defined. Antifungal compounds have been …

The opportunistic fungal pathogen Aspergillus fumigatus utilizes two high-affinity iron uptake
mechanisms, termed reductive iron assimilation (RIA) and siderophore-mediated iron …

Siderophores play an important role in fungal virulence, serving as trackers for in vivo
imaging and as biomarkers of fungal infections. However, siderophore uptake is only …