[HTML][HTML] Biomedical applications of engineered heparin-based materials

EN Zare, D Khorsandi, A Zarepour, H Yilmaz… - Bioactive Materials, 2024 - Elsevier
Heparin is a negatively charged polysaccharide with various chain lengths and a hydrophilic
backbone. Due to its fascinating chemical and physical properties, nontoxicity …

Versatile types of polysaccharide-based drug delivery systems: From strategic design to cancer therapy

Y Sun, X Jing, X Ma, Y Feng, H Hu - International Journal of Molecular …, 2020 - mdpi.com
Chemotherapy is still the most direct and effective means of cancer therapy nowadays. The
proposal of drug delivery systems (DDSs) has effectively improved many shortcomings of …

Tumor microenvironment-responsive PEGylated heparin-pyropheophorbide-a nanoconjugates for photodynamic therapy

Y Wu, F Li, X Zhang, Z Li, Q Zhang, W Wang, D Pan… - Carbohydrate …, 2021 - Elsevier
To deliver photosensitizers with PEGylated heparin (HP) into tumor cells for photodynamic
therapy, we prepared two polyethylene glycol (PEG)-functionalized HP-based polymers …

An overview of antitumour activity of polysaccharides

H Jin, M Li, F Tian, F Yu, W Zhao - Molecules, 2022 - mdpi.com
Cancer incidence and mortality are rapidly increasing worldwide; therefore, effective
therapies are required in the current scenario of increasing cancer cases. Polysaccharides …

Cryogels: recent applications in 3D-bioprinting, injectable cryogels, drug delivery, and wound healing

LO Jones, L Williams, T Boam… - Beilstein Journal of …, 2021 - beilstein-journals.org
Cryogels are macroporous polymeric structures formed from the cryogelation of
monomers/polymers in a solvent below freezing temperature. Due to their inherent …

Cryogel biomaterials for neuroscience applications

D Eigel, C Werner, B Newland - Neurochemistry international, 2021 - Elsevier
Biomaterials in the form of 3D polymeric scaffolds have been used to create structurally and
functionally biomimetic constructs of nervous system tissue. Such constructs can be used to …

Local delivery to malignant brain tumors: Potential biomaterial-based therapeutic/adjuvant strategies

M Alghamdi, M Gumbleton, B Newland - Biomaterials Science, 2021 - pubs.rsc.org
Glioblastoma (GBM) is the most aggressive malignant brain tumor and is associated with a
very poor prognosis. The standard treatment for newly diagnosed patients involves total …

Shape memory injectable cryogel based on carboxymethyl chitosan/gelatin for minimally invasive tissue engineering: In vitro and in vivo assays

N Olov, H Mirzadeh, R Moradi, S Rajabi… - … Research Part B …, 2022 - Wiley Online Library
Shape‐memory cryogels have drawn attention as an injectable system to minimize the risks
associated with surgical implantation in tissue engineering. To achieve shape memory …

Injectable glycosaminoglycan-based cryogels from well-defined microscale templates for local growth factor delivery

B Newland, H Newland, F Lorenzi, D Eigel… - ACS chemical …, 2021 - ACS Publications
Glycosaminoglycan-based hydrogels hold great potential for applications in tissue
engineering and regenerative medicine. By mimicking the natural extracellular matrix …

[HTML][HTML] Cryogel microcarriers for sustained local delivery of growth factors to the brain

A Hakami, K Narasimhan, G Comini, J Thiele… - Journal of Controlled …, 2024 - Elsevier
Neurotrophic growth factors such as glial cell line-derived neurotrophic factor (GDNF) and
brain-derived neurotrophic factor (BDNF) have been considered as potential therapeutic …