Lysophosphatidic acid (LPA) activates six LPA receptors (LPAR 1-6) and regulates various
cellular activities such as cell proliferation, cytoprotection, and wound healing. Many studies …

G protein-coupled receptors (GPCRs) are a large family of cell surface receptors that are the
targets for many different classes of pharmacotherapy. The islets of Langerhans are central …

Background In the extracellular environment, lysophosphatidic acid (LPA) species are
generated via autotaxin (ATX)-mediated hydrolysis of lysophospholipid precursors …

Toxoplasma gondii is a resilient parasite that infects a multitude of warm-blooded hosts and
results in a lifelong chronic infection requiring continuous responses by the host. Chronic …

Stroke is a major public health problem leading to high rates of death and disability
worldwide, but no effective pharmacological therapy is currently available except for the use …

Lysophosphatidic acid (LPA) is a bioactive lipid mediator that regulates a variety of cellular
functions such as cell proliferation, migration, survival, calcium mobilization, cytoskeletal …

Lysophosphatidic acid (LPA) is an endogenous bioactive lipid that is produced
extracellularly and signals to cells via cognate LPA receptors, which are G‐protein coupled …

Background The loss of endothelial integrity increases the risk of intracerebral hemorrhage
during ischemic stroke. Adjunct therapeutic targets for reperfusion in ischemic stroke are in …

Activation of microglia and/or astrocytes often releases proinflammatory molecules as critical
pathogenic mediators that can promote neuroinflammation and secondary brain damages in …

Lysophosphatidic acids (LPAs) are bioactive phospholipids implicated in a wide range of
cellular activities that regulate a diverse array of biological functions. They recognize two …