Carbonic anhydrases (CAs, EC 4.2. 1.1) catalyse the interconversion between CO2 and
bicarbonate as well as other hydrolytic reactions. Among the six genetic families known to …

Six genetic families of the enzyme carbonic anhydrase (CA, EC 4.2. 1.1) were described to
date. Inhibition of CAs has pharmacologic applications in the field of antiglaucoma …

Introduction: The enzyme carbonic anhydrase (CA, EC 4.2. 1.1) is found in numerous
organisms across the tree of life, with seven distinct classes known to date. CA inhibition can …

This article is a systematic review of reverse screening methods used to search for the
protein targets of chemopreventive compounds or drugs. Typical chemopreventive …

A set of compounds incorporating carbon-based zinc-binding groups (ZBGs), of the type
PhX (X= COOH, CONH2, CONHNH2, CONHOH, CONHOMe), and the corresponding …

Human carbonic anhydrases (CA, EC, 4.2. 1.1) IX and XII are overexpressed in cancer cells
as adaptive response to hypoxia and acidic conditions characteristic of many tumors. In …

Human carbonic anhydrase (hCA, EC 4.2. 1.1) isoforms IX and XII are overexpressed in
solid hypoxic tumors, and they are considered as prognostic tools and therapeutic targets for …

Famotidine, an antiulcer drug belonging to the H2 antagonists class of pharmacological
agents, was recently shown to potently inhibit human (h) and bacterial carbonic anhydrases …

In academia, compound recycling represents an alternative drug discovery strategy to
identify new pharmaceutical targets from a library of chemical compounds available in …

A series of phenolic acids and some of their esters, derivatives of caffeic, ferulic, and p-
coumaric acid, was investigated for the inhibition of three β-carbonic anhydrases (CAs, EC …