Insulin and insulin-like growth factor 1 (IGF1) signalling play a central role in the
development and maintenance of neurons in the brain, and in humans neurodevelopmental …

Understanding the complexities of the human brain and its associated disorders poses a
significant challenge in neuroscience. Traditional research methods have limitations in …

Simple Summary Multielectrode array technology allows researchers to record the
spontaneous firing activity of cultured neurons over a period of multiple weeks or months …

Heterozygous loss-of-function (LoF) mutations in SETD1A, which encodes a subunit of
histone H3 lysine 4 methyltransferase, cause a neurodevelopmental syndrome and increase …

Fragile X syndrome (FXS), the most prevalent heritable form of intellectual disability, is
caused by the transcriptional silencing of the FMR1 gene. While neuronal contribution to …

Cholesterol is an essential membrane structural component and steroid hormone precursor,
and is involved in numerous signaling processes. Astrocytes regulate brain cholesterol …

In vitro neuronal models have become an important tool to study healthy and diseased
neuronal circuits. The growing interest of neuroscientists to explore the dynamics of …

Introduction The neurodevelopmental disorder fragile X syndrome (FXS) is the most
common monogenic cause of intellectual disability associated with autism spectrum …

Autism spectrum disorder (ASD) represents a group of neurodevelopmental diseases
characterized by persistent deficits in social communication, interaction, and repetitive …

Fragile X syndrome (FXS) is a genetic neurodevelopmental disorder characterized by
intellectual disability and is related to autism. FXS is caused by mutations of the fragile X …