Although classically appreciated for their role as the powerhouse of the cell, the metabolic
functions of mitochondria reach far beyond bioenergetics. In this Review, we discuss how …

Cancer cells often upregulate nutrient transporters to fulfill their increased biosynthetic and
bioenergetic needs, and to maintain redox homeostasis. One nutrient transporter frequently …

Glycolysis, including both lactate fermentation and pyruvate oxidation, orchestrates CD8+ T
cell differentiation. However, how mitochondrial pyruvate metabolism and uptake controlled …

Serine, glycine and other nonessential amino acids are critical for tumour progression, and
strategies to limit their availability are emerging as potential therapies for cancer,–. However …

Mitochondria are bioenergetic, biosynthetic, and signaling organelles that are integral in
stress sensing to allow for cellular adaptation to the environment. Therefore, it is not …

Tumors reprogram pathways of nutrient acquisition and metabolism to meet the
bioenergetic, biosynthetic, and redox demands of malignant cells. These reprogrammed …

Pyruvate is the end-product of glycolysis, a major substrate for oxidative metabolism, and a
branching point for glucose, lactate, fatty acid and amino acid synthesis. The mitochondrial …

Activation of oncogenes and loss of tumour suppressors promote metabolic reprogramming
in cancer, resulting in enhanced nutrient uptake to supply energetic and biosynthetic …

Tumour cells have exquisite flexibility in reprogramming their metabolism in order to support
tumour initiation, progression, metastasis and resistance to therapies. These reprogrammed …

It is generally accepted that metabolism is able to shape the immune response. Only
recently we are gaining awareness that the metabolic crosstalk between different tumor …