Chromosome Duplication in Saccharomyces cerevisiae

SP Bell, K Labib - Genetics, 2016 - academic.oup.com
The accurate and complete replication of genomic DNA is essential for all life. In eukaryotic
cells, the assembly of the multi-enzyme replisomes that perform replication is divided into …

Eukaryotic chromosome DNA replication: where, when, and how?

H Masai, S Matsumoto, Z You… - Annual review of …, 2010 - annualreviews.org
DNA replication is central to cell proliferation. Studies in the past six decades since the
proposal of a semiconservative mode of DNA replication have confirmed the high degree of …

Replication-coupled DNA-protein crosslink repair by SPRTN and the proteasome in Xenopus egg extracts

NB Larsen, AO Gao, JL Sparks, I Gallina, RA Wu… - Molecular cell, 2019 - cell.com
DNA-protein crosslinks (DPCs) are bulky lesions that interfere with DNA metabolism and
therefore threaten genomic integrity. Recent studies implicate the metalloprotease SPRTN in …

Conjugative DNA metabolism in Gram-negative bacteria

F De La Cruz, LS Frost, RJ Meyer… - FEMS microbiology …, 2010 - academic.oup.com
Bacterial conjugation in Gram-negative bacteria is triggered by a signal that connects the
relaxosome to the coupling protein (T4CP) and transferosome, a type IV secretion system …

Structures and operating principles of the replisome

Y Gao, Y Cui, T Fox, S Lin, H Wang, N de Val, ZH Zhou… - Science, 2019 - science.org
INTRODUCTION DNA replication has been studied since the 1950s. It is well established
that double-helical DNA needs to be separated for replication by a helicase. Each strand is …

Cellular DNA replicases: components and dynamics at the replication fork

A Johnson, M O'Donnell - Annu. Rev. Biochem., 2005 - annualreviews.org
▪ Abstract Chromosomal DNA replicases are multicomponent machines that have evolved
clever strategies to perform their function. Although the structure of DNA is elegant in its …

Reductive genome evolution in Buchnera aphidicola

RCHJ Van Ham, J Kamerbeek… - Proceedings of the …, 2003 - National Acad Sciences
We have sequenced the genome of the intracellular symbiont Buchnera aphidicola from the
aphid Baizongia pistacea. This strain diverged 80–150 million years ago from the common …

[HTML][HTML] Independent and stochastic action of DNA polymerases in the replisome

JE Graham, KJ Marians, SC Kowalczykowski - Cell, 2017 - cell.com
It has been assumed that DNA synthesis by the leading-and lagging-strand polymerases in
the replisome must be coordinated to avoid the formation of significant gaps in the nascent …

Initiation of eukaryotic DNA replication: origin unwinding and sequential chromatin association of Cdc45, RPA, and DNA polymerase α

J Walter, J Newport - Molecular cell, 2000 - cell.com
We report that a plasmid replicating in Xenopus egg extracts becomes negatively
supercoiled during replication initiation. Supercoiling requires the initiation factor Cdc45, as …

Replisome-mediated DNA replication

SJ Benkovic, AM Valentine… - Annual review of …, 2001 - annualreviews.org
▪ Abstract The elaborate process of genomic replication requires a large collection of
proteins properly assembled at a DNA replication fork. Several decades of research on the …