Pathogenesis of human cytomegalovirus in the immunocompromised host

P Griffiths, M Reeves - Nature Reviews Microbiology, 2021 - nature.com
Human cytomegalovirus (HCMV) is a herpesvirus that infects~ 60% of adults in developed
countries and more than 90% in developing countries. Usually, it is controlled by a vigorous …

Human cytomegalovirus haplotype reconstruction reveals high diversity due to superinfection and evidence of within-host recombination

J Cudini, S Roy, CJ Houldcroft… - Proceedings of the …, 2019 - National Acad Sciences
Recent sequencing efforts have led to estimates of human cytomegalovirus (HCMV)
genome-wide intrahost diversity that rival those of persistent RNA viruses [Renzette N …

Defining the transcriptional landscape during cytomegalovirus latency with single-cell RNA sequencing

M Shnayder, A Nachshon, B Krishna, E Poole… - MBio, 2018 - Am Soc Microbiol
Primary infection with human cytomegalovirus (HCMV) results in a lifelong infection due to
its ability to establish latent infection, with one characterized viral reservoir being …

Crystal structure of the human cytomegalovirus glycoprotein B

HG Burke, EE Heldwein - PLoS pathogens, 2015 - journals.plos.org
Human cytomegalovirus (HCMV), a dsDNA, enveloped virus, is a ubiquitous pathogen that
establishes lifelong latent infections and caused disease in persons with compromised …

Development of a vaccine against human cytomegalovirus: advances, barriers, and implications for the clinical practice

S Scarpini, F Morigi, L Betti, A Dondi, C Biagi, M Lanari - Vaccines, 2021 - mdpi.com
Human cytomegalovirus (hCMV) is one of the most common causes of congenital infection
in the post-rubella era, representing a major public health concern. Although most cases are …

Fetal cytomegalovirus infection

M Leruez-Ville, Y Ville - Best practice & research Clinical obstetrics & …, 2017 - Elsevier
Highlights•Recent data highlight the true burden of non-primary maternal infection in
congenital CMV infection.•Accurate diagnosis of maternal primary infection is …

Human cytomegalovirus genomes sequenced directly from clinical material: variation, multiple-strain infection, recombination, and gene loss

NM Suárez, GS Wilkie, E Hage… - The Journal of …, 2019 - academic.oup.com
The genomic characteristics of human cytomegalovirus (HCMV) strains sequenced directly
from clinical pathology samples were investigated, focusing on variation, multiple-strain …

High-risk oncogenic human cytomegalovirus

G Herbein - Viruses, 2022 - mdpi.com
Human cytomegalovirus (HCMV) is a herpesvirus that infects between 40% and 95% of the
population worldwide, usually without symptoms. The host immune response keeps the …

Drug resistance mutations and associated phenotypes detected in clinical trials of maribavir for treatment of cytomegalovirus infection

S Chou, K Song, J Wu, T Bo… - The Journal of infectious …, 2022 - academic.oup.com
Background In separate phase 2 trials, 120 patients received maribavir for cytomegalovirus
(CMV) infection failing conventional therapy (trial 202) and 119 received maribavir for …

Genomic and geographical structure of human cytomegalovirus

OJ Charles, C Venturini, S Gantt… - Proceedings of the …, 2023 - National Acad Sciences
Human cytomegalovirus (CMV) has infected humans since the origin of our species and
currently infects most of the world's population. Variability between CMV genomes is the …