Critical illness polyneuropathies (CIP) and myopathies (CIM) are common complications of
critical illness. Several weakness syndromes are summarized under the term intensive care …

Skeletal muscle atrophy attributable to muscular inactivity has significant adverse functional
consequences. While the initiating physiological event leading to atrophy seems to be the …

Muscle wasting negatively affects morbidity and mortality in critically ill patients. This
progressive wasting is accompanied by, in general, a normal muscle PS (protein synthesis) …

Dexamethasone‐treated L6 (a rat cell line) and C2C12 (a mouse cell line) myotubes are
frequently used as in vitro models of muscle wasting. We compared the effects of different …

Cachexia is a progressive wasting syndrome characterized by extensive loss of adipose
tissue and skeletal muscle. It occurs in about half of all cancer patients. While anorexia also …

Skeletal muscle wasting is a prominent feature of cachexia, a complex systemic syndrome
that frequently complicates chronic diseases such as inflammatory and autoimmune …

Loss of functional capacity of skeletal muscle is a major cause of morbidity in patients with a
number of acute and chronic clinical disorders, including sepsis, chronic obstructive …

Mutations in the non-lysosomal cysteine protease calpain 3 cause limb-girdle muscular
dystrophy type 2A (LGMD2A). Our previous studies of the calpain 3 knockout mouse (C3KO) …

The catabolic response to sepsis, severe injury, and burn is characterized by whole-body
protein loss, mainly reflecting increased breakdown of muscle proteins, in particular …

Skeletal muscle atrophy is a common side effect of most human diseases. Muscle loss is not
only detrimental for the quality of life but it also dramatically impairs physiological processes …