Platelet factor 4 (PF4) and its multiple roles in diseases

Z Liu, L Li, H Zhang, X Pang, Z Qiu, Q Xiang, Y Cui - Blood Reviews, 2023 - Elsevier
Abstract Platelet factor 4 (PF4) combines with heparin to form an antigen that could produce
IgG antibodies and participate in heparin-induced thrombocytopenia (HIT). PF4 has …

Vaccine-induced immune thrombotic thrombocytopenia: what do we know hitherto?

R Roytenberg, A García-Sastre, W Li - Frontiers in medicine, 2023 - frontiersin.org
Vaccine-induced immune thrombotic thrombocytopenia (VITT), also known as thrombosis
with thrombocytopenia syndrome, is a catastrophic and life-threatening reaction to …

Severe COVID-19 patients exhibit elevated levels of autoantibodies targeting cardiolipin and platelet glycoprotein with age: a systems biology approach

DLM Fonseca, IS Filgueiras, AHC Marques, E Vojdani… - npj Aging, 2023 - nature.com
Age is a significant risk factor for the coronavirus disease 2019 (COVID-19) severity due to
immunosenescence and certain age-dependent medical conditions (eg, obesity …

Mechanisms of COVID-19 associated pulmonary thrombosis: a narrative review

CM Niculae, A Hristea, R Moroti - Biomedicines, 2023 - mdpi.com
COVID-19, the infectious disease caused by severe acute respiratory syndrome coronavirus-
2 (SARS-CoV-2), is frequently associated with pulmonary thrombotic events, especially in …

Autoimmune complications of COVID-19 and potential consequences for long-lasting disease syndromes

J Amiral, J Seghatchian - Transfusion and Apheresis Science, 2023 - Elsevier
The latest WHO report determined the increasing diversity within the CoV-2 omicron and its
descendent lineages. Some heavily mutated offshoots of BA. 5 and BA. 2, such as BA. 4.6 …

The immunology of PF4 polyanion interactions

ATP Ngo, V Bochenek, K Gollomp - Current Opinion in …, 2023 - journals.lww.com
The immunology of PF4 polyanion interactions : Current Opinion in Hematology The
immunology of PF4 polyanion interactions : Current Opinion in Hematology Log in or Register …

Pro-thrombotic autoantibodies targeting Platelet Factor 4/polyanion are associated with pediatric cerebral malaria

IM Vera, A Kessler, V Harawa… - The Journal of …, 2024 - Am Soc Clin Investig
BACKGROUND. Features of consumptive coagulopathy and thromboinflammation are
prominent in cerebral malaria (CM). We hypothesized that thrombogenic autoantibodies …

[HTML][HTML] Thrombocytopenia is associated with a dysregulated host response in severe COVID-19

B Appelman, EHA Michels, J de Brabander… - Thrombosis research, 2023 - Elsevier
Background Thrombocytopenia is associated with increased mortality in COVID-19 patients.
Objective To determine the association between thrombocytopenia and alterations in host …

Transient Autoreactive PF4 and Antiphospholipid Antibodies in COVID-19 Vaccine Recipients

MP Raadsen, C Visser, AHA Lavell… - Vaccines, 2023 - mdpi.com
Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare autoimmune
condition associated with recombinant adenovirus (rAV)-based COVID-19 vaccines. It is …

SARS-CoV-2 infection induces the production of autoantibodies in severe COVID-19 patients in an age-dependent manner

DLM Fonseca, IS Filgueiras, AHC Marques, E Vojdani… - medRxiv, 2022 - medrxiv.org
Age is a significant risk factor for the coronavirus disease 2019 (COVID-19) outcomes due to
immunosenescence and certain age-dependent medical conditions (eg, obesity …