[HTML][HTML] Smad3 signatures in renal inflammation and fibrosis

W Wu, X Wang, X Yu, HY Lan - International journal of biological …, 2022 - ncbi.nlm.nih.gov
Renal inflammation and fibrosis are key pathological features of acute kidney injury (AKI)
and chronic kidney disease (CKD). Smad3 is a critical mediator of TGF-β signaling and …

Pharmacological properties, molecular mechanisms, and pharmaceutical development of asiatic acid: a pentacyclic triterpenoid of therapeutic promise

MF Nagoor Meeran, SN Goyal, K Suchal… - Frontiers in …, 2018 - frontiersin.org
Asiatic acid (AA) is a naturally occurring aglycone of ursane type pentacyclic triterpenoids. It
is abundantly present in many edible and medicinal plants including Centella asiatica that is …

Pentacyclic Triterpenoids from the Medicinal Herb, Centella asiatica (L.) Urban

JT James, IA Dubery - Molecules, 2009 - mdpi.com
Centella asiatica accumulates large quantities of pentacyclic triterpenoid saponins,
collectively known as centelloids. These terpenoids include asiaticoside, centelloside …

Triterpene Composition and Bioactivities of Centella asiatica

P Hashim, H Sidek, MHM Helan, A Sabery… - Molecules, 2011 - mdpi.com
Leaves of Centella asiatica (Centella) were analysed for their triterpene composition and
bioactivity such as collagen enhancement, antioxidant, anticellulite and UV protection …

Ethnobotany, phytochemistry, pharmacology, and toxicity of Centella asiatica (L.) Urban: A comprehensive review

D Biswas, S Mandal, S Chatterjee Saha… - Phytotherapy …, 2021 - Wiley Online Library
The well‐known medicinal plant Centella asiatica (L.) Urban is an Ayurvedic and traditional
Chinese medicine used in the treatment of different health problems and as an edible …

[PDF][PDF] CENTELLA ASIATICA (L.): A PLANT W ITH IM M ENSE M EDICINAL POTENTIAL BUT THREATENED

S Singh, A Gautam, A Sharma, A Batra - endangered species, 2010 - academia.edu
Centella asiatica (L.) is a perennial, creeper, faintly aromatic and a valuable medicinal herb
of both Old World and the New World. It is distributed throughout tropical and subtropical …

Medicinally important aromatic plants with radioprotective activity

RM Samarth, M Samarth, Y Matsumoto - Future science OA, 2017 - Taylor & Francis
Aromatic plants are often used as natural medicines because of their remedial and inherent
pharmacological properties. Looking into natural resources, particularly products of plant …

Asiatic Acid Inhibits Liver Fibrosis by Blocking TGF-beta/Smad Signaling In Vivo and In Vitro

L Tang, R He, G Yang, J Tan, L Zhou, X Meng… - PloS one, 2012 - journals.plos.org
Liver fibrosis is a major cause of liver failure, but treatment remains ineffective. In the present
study, we investigated the mechanisms and anti-hepatofibrotic activities of asiatic acid (AA) …

Chemical Composition and Antibacterial Activity of the Essential Oil of Centella asiatica. Growing in South Africa

OA Oyedeji, AJ Afolayan - Pharmaceutical biology, 2005 - Taylor & Francis
ABSTRACT In South Africa, Centella asiatica.(L.) Urb is used traditionally for the treatment of
various diseases. Analyses of the essential oil of this medicinal plant revealed 11 …

Efficacy of asiatic acid, a pentacyclic triterpene on attenuating the key enzymes activities of carbohydrate metabolism in streptozotocin-induced diabetic rats

V Ramachandran, R Saravanan - Phytomedicine, 2013 - Elsevier
Asiatic acid (AA), a triterpenoid derivative of Centella asiatica, has shown significant
biological effects of antioxidant and anti-inflammatory activities. Aim of this investigation was …