[HTML][HTML] Age-related macular degeneration: Epidemiology, genetics, pathophysiology, diagnosis, and targeted therapy

Y Deng, L Qiao, M Du, C Qu, L Wan, J Li, L Huang - Genes & diseases, 2022 - Elsevier
Age-related macular degeneration (AMD) is a complex eye disorder and is the leading
cause of incurable blindness worldwide in the elderly. Clinically, AMD initially affects the …

Smoking and age‐related macular degeneration: review and update

S Velilla, JJ García-Medina… - Journal of …, 2013 - Wiley Online Library
Age‐related macular degeneration (AMD) is one of the main socioeconomical health issues
worldwide. AMD has a multifactorial etiology with a variety of risk factors. Smoking is the …

The incidence of neovascular subtypes in newly diagnosed neovascular age-related macular degeneration

JJ Jung, CY Chen, S Mrejen, R Gallego-Pinazo… - American journal of …, 2014 - Elsevier
Purpose To determine the frequency of neovascularization subtypes as determined by
fluorescein angiography (FA) alone vs FA and optical coherence tomography (OCT) grading …

Exploring the contribution of ARMS2 and HTRA1 genetic risk factors in age-related macular degeneration

Y Pan, Y Fu, PN Baird, RH Guymer, T Das… - Progress in Retinal and …, 2023 - Elsevier
Age-related macular degeneration (AMD) is the leading cause of severe irreversible central
vision loss in individuals over 65 years old. Genome-wide association studies (GWASs) …

Age-related macular degeneration and the complement system

S Khandhadia, V Cipriani, JRW Yates, AJ Lotery - Immunobiology, 2012 - Elsevier
Age-related macular degeneration (AMD) is the leading cause of blindness in the developed
world. It is a complex multifactorial disease, and despite new advances in treatment, many …

Complement in age-related macular degeneration: a focus on function

DT Bradley, PF Zipfel, AE Hughes - Eye, 2011 - nature.com
Age-related macular degeneration (AMD) is an inflammatory disease, which causes visual
impairment and blindness in older people. The proteins of the complement system are …

[HTML][HTML] The phenotypic course of age-related macular degeneration for ARMS2/HTRA1: the EYE-RISK consortium

EF Thee, JM Colijn, A Cougnard-Grégoire… - Ophthalmology, 2022 - Elsevier
Purpose Age-related maculopathy susceptibility 2 (ARMS2) is considered the most
enigmatic of the genes for age-related macular degeneration (AMD). We investigated the …

Vitreomacular adhesion in active and end-stage age-related macular degeneration

CD Robison, I Krebs, S Binder, IA Barbazetto… - American journal of …, 2009 - Elsevier
PURPOSE: To evaluate vitreomacular relations in different stages of age-related macular
degeneration (AMD) without the influence of genetics and environmental factors. DESIGN …

Genetic and Functional Dissection of HTRA1 and LOC387715 in Age-Related Macular Degeneration

Z Yang, Z Tong, Y Chen, J Zeng, F Lu, X Sun… - PLoS …, 2010 - journals.plos.org
A common haplotype on 10q26 influences the risk of age-related macular degeneration
(AMD) and encompasses two genes, LOC387715 and HTRA1. Recent data have suggested …

Age related macular degeneration

U Chakravarthy, J Evans, PJ Rosenfeld - Bmj, 2010 - bmj.com
Standard care for neovascular age related macular degeneration is treatment with
monoclonal antibodies that inhibit vascular endothelial growth factor. A fifth of those treated …