Multidrug resistance (MDR) is a serious problem that hampers the success of cancer
pharmacotherapy. A common mechanism is the overexpression of ATP-binding cassette …

In theory, in vitro and in vivo models for human gliomas have great potential to not only
enhance our understanding of glioma biology, but also to facilitate the development of novel …

J. Neurochem.(2011) 117, 333–345. Abstract We have obtained, for the first time, a
quantitative protein expression profile of membrane transporters and receptors in human …

Three ATP-binding cassette (ABC)-superfamily multidrug efflux pumps are known to be
responsible for chemoresistance; P-glycoprotein (ABCB1), MRP1 (ABCC1) and ABCG2 …

Glioblastoma (GBM) is a lethal and aggressive brain tumor that is resistant to conventional
radiation and cytotoxic chemotherapies. Molecularly targeted agents hold great promise in …

Our body keeps separating the toxic chemicals in the blood from the brain. A significant
number of drugs do not enter the central nervous system (CNS) due to the blood-brain …

Since cloning of the ATP-binding cassette (ABC) family member breast cancer resistance
protein (BCRP/ABCG2) and its characterization as a multidrug resistance efflux transporter …

In this review we give an overview of the physiological functions of a group of ATP binding
cassette (ABC) transporter proteins, which were discovered, and still referred to, as …

Despite scientific advances in understanding the causes and treatment of human
malignancy, a persistent challenge facing basic and clinical investigators is how to …

In the past decade, many tyrosine-kinase inhibitors have been introduced in oncology and
haemato-oncology. Because this new class of drugs is extensively used, serious drug–drug …