Tissues and organs are composed of distinct cell types that must operate in concert to
perform physiological functions. Efforts to create high-dimensional biomarker catalogs of …

The second decade of the twenty-first century witnessed a new challenge in the handling of
microscopy data. Big data, data deluge, large data, data compliance, data analytics, data …

Despite the huge impact of data resources in genomics and structural biology, until now
there has been no central archive for biological data for all imaging modalities. The …

The imminent release of tissue atlases combining multichannel microscopy with single-cell
sequencing and other omics data from normal and diseased specimens creates an urgent …

The community-driven initiative Quality Assessment and Reproducibility for Instruments &
Images in Light Microscopy (QUAREP-LiMi) wants to improve reproducibility for light …

Deep learning is emerging as a powerful approach for bioimage analysis. Its use in cell
tracking is limited by the scarcity of annotated data for the training of deep-learning models …

A modern day light microscope has evolved from a tool devoted to making primarily
empirical observations to what is now a sophisticated, quantitative device that is an integral …

Rigorous record-keeping and quality control are required to ensure the quality,
reproducibility and value of imaging data. The 4DN Initiative and BINA here propose light …

Detailed knowledge of biological structure has been key in understanding biology at several
levels of organisation, from organs to cells and proteins. Volume electron microscopy …

From the combined perspective of biologists, microscope instrumentation developers,
imaging core facility scientists, and high performance computing experts, we discuss the …