Recently, there has been an increasing amount of literature published on the effects of 4-
phenylbutyric acid (4-PBA) in various biological systems. 4-PBA is currently used clinically to …

We develop multidrug-loaded cubosome and spongosome lipid nanoparticles for targeting
of endoplasmic reticulum stress as a potential emerging therapeutic strategy against …

The cytoplasmic accumulation of the nuclear TAR DNA-binding protein 43 (TDP-43) is a
pathologic hallmark in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and …

Abstract Endoplasmic reticulum protein 29 (ERp29) belongs to the redox-inactive PDI-Dβ-
subfamily of PDI-proteins. ERp29 is expressed in all mammalian tissues examined …

Antipsychotics are the most important treatment for schizophrenia. However, antipsychotics,
particularly olanzapine and clozapine, are associated with severe weight gain/obesity side …

Endoplasmic reticulum (ER) stress induced by disruption of protein folding activates the
unfolded protein response (UPR), which while generally pro-survival in effect can also …

Intervertebral disc (IVD) degeneration is closely related to inflammatory cytokines, such as
tumor necrosis factor alpha (TNF-α). The endoplasmic reticulum (ER) serves several …

The physico-chemical characteristics of the extracellular matrix (ECM) cause mechanical
cues that could elicit responses in the survival rate of cortical neuronal cells. Efficient neurite …

Familial encephalopathy with neuroserpin inclusion bodies (FENIB) is a rare disease
characterized by the deposition of multiple intracytoplasmic neuronal inclusions that contain …

Effects of airborne particles on the expression status of markers of cellular toxic stress and
on the release of eicosanoids, linked with inflammation and oxidative damage, remain …