During ontogeny, γδ T cells emerge from the thymus and directly seed peripheral tissues for
in situ immunity. However, their functional role in humans has largely been defined from …

The development and deployment of single-cell genomic technologies have driven a
resolution revolution in our understanding of the immune system, providing unprecedented …

Immune memory—comprising T cells, B cells and plasma cells and their secreted antibodies—
is crucial for human survival. It enables the rapid and effective clearance of a pathogen after …

Peripheral helper T (Tph) cells have been established, through intensive efforts to elucidate
local immune responses in human rheumatoid arthritis (RA), as a CD4 subset intimately …

Neither immunization nor recovery from natural infection provides life-long protection
against Bordetella pertussis. Replacement of a whole-cell pertussis (wP) vaccine with an …

HIV and TB are the cause of significant worldwide mortality and pose a grave danger to the
global public health. TB is the leading cause of death in HIV-infected persons, with one in …

Immune responses in early life are characterized by a failure to robustly generate long-
lasting protective responses against many common pathogens or upon vaccination. This is …

Abstract The Human BioMolecular Atlas Program (HuBMAP) aims to construct a reference
3D structural, cellular, and molecular atlas of the healthy adult human body. The HuBMAP …

Rotavirus infection continues to be a significant public health problem in developing
countries, despite the availability of several vaccines. The efficacy of oral rotavirus vaccines …

Emerging studies have highlighted the importance of tissue-resident B cells in the lungs for
protective immunity against respiratory viruses. However, mechanisms controlling …