Genomic instability in disease and its fidelity in health depend on the DNA damage
response (DDR), regulated in part from the complex of meiotic recombination 11 homolog 1 …

Genome instability is a hallmark of cancer cells and can be accelerated by defects in cellular
responses to DNA damage. This feature of malignant cells opens new avenues for tumor …

Radioresistance is the main obstacle in the clinical management of nasopharyngeal
carcinoma (NPC). linc00312 is deregulated in a number of human cancers, including NPC …

Breast cancer is the most common malignancy in women all over the world. Genetic
background of women contributes to her risk of having breast cancer. Certain inherited DNA …

Ectopic R-loop accumulation causes DNA replication stress and genome instability. To
avoid these outcomes, cells possess a range of anti-R-loop mechanisms, including RNaseH …

Purpose The aim of this work is to review the published studies on radiation resistance
mechanisms and molecular markers involved in different tumors. The revision has been …

The MRE11-RAD50-NBS1 (MRN) complex has been studied in multiple cancers. The
identification of MRN complex mutations in mismatch repair (MMR)-defective cancers has …

Human epidermal growth factor receptor 2 (HER2/ERBB2) factor is known to be implicated
in many malignancies and the potential of it as a prognostic biomarker was reported years …

Purpose: The MEK inhibitor trametinib radiosensitizes KRAS-mutant non–small cell lung
cancer (NSCLC) and is being tested clinically with chemoradiation. However, variability in …

Rad50 is a component of MRN (Mre11‐Rad50‐Nbs1), which participates in DNA double‐
strand break repair and DNA‐damage checkpoint activation. Here, we sought to investigate …