The MRE11–RAD50–NBS1 complex conducts the orchestration of damage signaling and outcomes to stress in DNA replication and repair

A Syed, JA Tainer - Annual review of biochemistry, 2018 - annualreviews.org
Genomic instability in disease and its fidelity in health depend on the DNA damage
response (DDR), regulated in part from the complex of meiotic recombination 11 homolog 1 …

MRE11-RAD50-NBS1 complex alterations and DNA damage response: implications for cancer treatment

L Bian, Y Meng, M Zhang, D Li - Molecular Cancer, 2019 - Springer
Genome instability is a hallmark of cancer cells and can be accelerated by defects in cellular
responses to DNA damage. This feature of malignant cells opens new avenues for tumor …

LncRNA linc00312 suppresses radiotherapy resistance by targeting DNA-PKcs and impairing DNA damage repair in nasopharyngeal carcinoma

Z Guo, YH Wang, H Xu, CS Yuan, HH Zhou… - Cell death & …, 2021 - nature.com
Radioresistance is the main obstacle in the clinical management of nasopharyngeal
carcinoma (NPC). linc00312 is deregulated in a number of human cancers, including NPC …

Recent advances of therapeutic targets based on the molecular signature in breast cancer: genetic mutations and implications for current treatment paradigms

ZS Lima, M Ghadamzadeh, FT Arashloo… - Journal of hematology & …, 2019 - Springer
Breast cancer is the most common malignancy in women all over the world. Genetic
background of women contributes to her risk of having breast cancer. Certain inherited DNA …

MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription–replication conflicts

EYC Chang, S Tsai, MJ Aristizabal, JP Wells… - Nature …, 2019 - nature.com
Ectopic R-loop accumulation causes DNA replication stress and genome instability. To
avoid these outcomes, cells possess a range of anti-R-loop mechanisms, including RNaseH …

Factors and molecular mechanisms of radiation resistance in cancer cells

JC Alamilla-Presuel, AM Burgos-Molina… - … Journal of Radiation …, 2022 - Taylor & Francis
Purpose The aim of this work is to review the published studies on radiation resistance
mechanisms and molecular markers involved in different tumors. The revision has been …

MRN (MRE11-RAD50-NBS1) complex in human cancer and prognostic implications in colorectal cancer

Y Situ, L Chung, CS Lee, V Ho - International journal of molecular …, 2019 - mdpi.com
The MRE11-RAD50-NBS1 (MRN) complex has been studied in multiple cancers. The
identification of MRN complex mutations in mismatch repair (MMR)-defective cancers has …

Homologous recombination mRNAs (RAD21, RAD50 and BARD1) have a potentially poor prognostic role in ERBB2-low bladder cancer patients

N Albarakati, H Al-Ghamdi, B Al-Sowayan… - Scientific Reports, 2023 - nature.com
Human epidermal growth factor receptor 2 (HER2/ERBB2) factor is known to be implicated
in many malignancies and the potential of it as a prognostic biomarker was reported years …

Mutant LKB1 confers enhanced radiosensitization in combination with trametinib in KRAS-mutant non–small cell lung cancer

Y Wang, N Li, W Jiang, W Deng, R Ye, C Xu… - Clinical Cancer …, 2018 - AACR
Purpose: The MEK inhibitor trametinib radiosensitizes KRAS-mutant non–small cell lung
cancer (NSCLC) and is being tested clinically with chemoradiation. However, variability in …

Rad50 promotes ovarian cancer progression through NF‐κB activation

Y Li, S Wang, P Li, Y Li, Y Liu, H Fang… - Journal of cellular …, 2021 - Wiley Online Library
Rad50 is a component of MRN (Mre11‐Rad50‐Nbs1), which participates in DNA double‐
strand break repair and DNA‐damage checkpoint activation. Here, we sought to investigate …