The investigation of macromolecular biomolecules with ion mobility mass spectrometry (IM-
MS) techniques has provided substantial insights into the field of structural biology over the …

Small molecule drug discovery has been propelled by the continual development of novel
scientific methodologies to occasion therapeutic advances. Although established …

Mass spectrometry is a central technology in the life sciences, providing our most
comprehensive account of the molecular inventory of the cell. In parallel with developments …

The analysis of peptides and proteins as well as the grander scope of proteomics (large
scale study of proteins) has been advanced by the development of a versatile array of ion …

The conformations of desolvated ubiquitin ions, lifted into the gas phase by electrospray
ionization (ESI), were characterized by ion mobility spectrometry (IMS) and compared to the …

This tutorial review describes the principles and practices of electron capture and transfer
dissociation (ECD/ETD or ExD) mass spectrometry (MS) employed for peptide and protein …

Progress in structural biology research has led to a high demand for powerful and yet
complementary analytical tools for structural characterization of proteins and protein …

The extent to which proteins in the gas phase retain their condensed-phase structure is a
hotly debated issue. Closely related to this is the degree to which the observed charge state …

Past experimental results and molecular dynamics simulations provide evidence that, under
some conditions, electrospray ionization (ESI) of biomolecules produces ions that retain …

The design of new therapeutic molecules can be significantly informed by studying protein-
ligand interactions using biophysical approaches directly after purification of the protein …