Summary Mannose‐binding lectin (MBL), collectin‐10, collectin‐11, and the ficolins (ficolin‐
1, ficolin‐2, and ficolin‐3) are soluble pattern recognition molecules in the lectin complement …

The innate immune system is the first line of host defense against infection and is comprised
of humoral and cellular mechanisms that recognize potential pathogens within minutes or …

Complement defects are associated with an enhanced risk of a broad spectrum of infectious
as well as systemic or local inflammatory and thrombotic disorders. Inherited complement …

Chagas disease (CD), a neglected tropical disease caused by the protozoan Trypanosoma
cruzi, affects around six million individuals in Latin America. Currently, CD occurs worldwide …

In the innate immune system, a variety of recognition molecules provide the first-line host
defense to prevent infection and maintain endogenous homeostasis. Ficolin is a soluble …

The lectin pathway of the complement system has a pivotal role in the defense against
infectious organisms. After binding of mannan-binding lectin (MBL), ficolins or collectin 11 to …

Ficolins are innate pattern recognition receptors (PRR) and play integral roles within the
innate immune response to numerous pathogens throughout the circulation, as well as …

Heart diseases are common and significant contributors to worldwide mortality and
morbidity. During recent years complement mediated inflammation has been shown to be an …

Chagas' disease is a zoonotic parasitic ailment now affecting more than 6 million people,
mainly in Latin America. Its agent, the protozoan Trypanosoma cruzi, is primarily transmitted …

Chagas disease (CD) is a chronic tropical disease caused by Trypanosoma cruzi, affecting
about 8 million people in Latin America. The lectin pathway (LP) of the complement system …