Reactive oxygen species (ROS), previously considered toxic by-products of aerobic
metabolism, are increasingly recognized as regulators of cellular signaling. Keeping ROS …

Acute lymphoblastic leukaemia (ALL) is the most common cancer diagnosed in children and
adolescents. Approximately 70% of patients survive> 5-years following diagnosis, however …

Acute lymphoblastic leukemia (ALL) is a hematological malignancy originating from B-or T-
lymphoid progenitor cells. Recent studies have shown that redox dysregulation caused by …

Cellular senescence is recognized as a dynamic process in which cells evolve and adapt in
a context dependent manner; consequently, senescent cells can exert both beneficial and …

Precursor B cell acute lymphoblastic leukemia (Pre-B-ALL) arises from developing B cells
and frequently involves mutations in genes encoding transcription factors. In this study, we …

Redox adaptation is essential for human health, as the physiological quantities of non-
radical reactive oxygen species operate as the main second messengers to regulate normal …

Precursor B cell acute lymphoblastic leukemia (pre-B-ALL) arises as a result of precursor B
cells acquiring driver mutations that lead to arrested differentiation and increased …

Activation-induced cytidine deaminase (AID, encoded by Aicda) plays a key role in somatic
hypermutation and class switch recombination in germinal center B cells. However, off-target …

Autophagy is a fundamental cellular process that maintains homeostasis by degrading
damaged components and regulating stress responses. It plays a crucial role in cancer …

B cell acute lymphoblastic leukemia (B-ALL) is the most prevalent type of cancer in young
children and is associated with recurrent mutations and high levels of reactive oxygen …