Since the seminal discovery of dendritic cells (DCs) by Steinman and Cohn in 1973, there
has been an ongoing debate to what extent macrophages and DCs are related and perform …

Type I interferons (IFN-I) are critical mediators of innate control of viral infections but also
drive the recruitment of inflammatory cells to sites of infection, a key feature of severe …

Sialic acids and heparan sulfates make up the outermost part of the cell membrane and the
extracellular matrix. Both structures are characterized by being negatively charged, serving …

Exacerbated and persistent innate immune response marked by pro-inflammatory cytokine
expression is thought to be a major driver of chronic COVID-19 pathology. Although …

Immunomodulatory Siglecs are controlled by their glycoprotein and glycolipid ligands.
Siglec-glycolipid interactions are often studied outside the context of a lipid bilayer, missing …

Interactions between sialylated glycans and sialic acid-binding immunoglobulin-like lectin
(Siglec) receptors have been recently described as potential new immune checkpoint that …

The interaction of the SARS CoV2 spike glycoprotein with two sialic acid‐containing
trisaccharides (α2, 3 and α2, 6 sialyl N‐acetyllactosamine) has been demonstrated by NMR …

Abstract Background SARS-CoV-2, the pathogen of COVID-19, is a worldwide threat to
human health and causes a long-term burden on the cardiovascular system. Individuals with …

Understanding the genetic basis of COVID-19 vaccine seroconversion is crucial to study the
role of genetics on vaccine effectiveness. In our study, we used UK Biobank data to find the …

CD169, also known as Siglec1 or Sialoadhesin (Sn), is a surface adhesion molecule on
human myeloid cells. Being part of the Siglec family, it acts as a receptor for sialylated …