Abstract Purpose of Review To summarize the current knowledge on the role that B
lymphocytes play in heart failure. Recent Findings Several studies from murine models have …

Allosteric regulation is critical for the functioning of G protein-coupled receptors (GPCRs)
and their signaling pathways. Endogenous allosteric regulators of GPCRs are simple ions …

Long COVID (LC) describes the clinical phenotype of symptoms after infection with the
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Diagnostic and therapeutic …

Background Idiopathic recurrent acute pericarditis (IRAP) is a rare disease of suspected, yet
unproved, immune-mediated origin. The finding of serum heart-specific autoantibodies in …

Agonistic autoantibodies (AABs) against G-protein-coupled receptor (GPCR) are present
mainly in diseases of the cardiovascular system or in diseases associated with …

Background Limited information exists on the role of B‐cell‐dependent mechanisms in the
progression of heart failure (HF). However, in failing human myocardium, there is evidence …

Since the original descriptions of the role of stromal cell-derived factor (SDF)-1 in recruiting
bone marrow derived stem cells to the sites of vascular1 and myocardial injury, 2 there has …

Autoimmune abnormalities, as well as viral infection and genetic abnormalities, appear to be
major predisposing factors for dilated cardiomyopathy (DCM). Abnormalities of cell …

Despite numerous demonstrations that the immune system is activated in heart failure,
negatively affecting patients' outcomes, no definitive treatment strategy exists directed to …

Antibodies that activate the β1-AR (β1-adrenoreceptor) can induce heart failure in animal
models. These antibodies are often found in patients with heart failure secondary to varying …