Cardiac surgery is associated with perioperative blood loss and a high risk of allogeneic
blood transfusion. Patient blood management (PBM) in cardiac surgery contributes to the …

Bleeding after cardiac surgery is a common and serious complication leading to transfusion
of multiple blood products and resulting in increased morbidity and mortality. Despite the …

Document Reviewers: Moritz WV Wyler von Ballmoos (USA), Mate Petricevic (Croatia), Arie
Pieter Kappetein (Netherlands), Miguel Sousa-Uva (Portugal), Georg Trummer (Germany) …

BACKGROUND: Practice guidelines reflect published literature. Because of the ever
changing literature base, it is necessary to update and revise guideline recommendations …

The aims of severe perioperative bleeding management are three-fold. First, preoperative
identification by anamesis and laboratory testing of those patients for whom the …

Cardiopulmonary bypass (CPB) has allowed for significant surgical advancements, but
accompanying risks can be significant and must be expertly managed. One of the foremost …

Background The use of recombinant activated factor VII (rFVIIa) on an off-label basis to treat
life-threatening bleeding has been associated with a perceived increased risk of …

Blood transfusion can be life‐saving. Anaesthetists regularly request and administer blood
components to their patients. All anaesthetists must be familiar with indications and …

Background In the ARISTOTLE trial, the rate of stroke or systemic embolism was reduced by
apixaban compared with warfarin in patients with atrial fibrillation (AF). Patients with AF and …

Perioperative bleeding remains a major complication during and after surgery, resulting in
increased morbidity and mortality. The principal causes of non-vascular sources of …