Natural inhibitors of PI3K/AKT signaling in breast cancer: emphasis on newly-discovered molecular mechanisms of action

Y Safdari, M Khalili, MA Ebrahimzadeh… - Pharmacological …, 2015 - Elsevier
Epidermal growth factor receptor (EGFR) plays a critical role in the initiation and progression
of a variety of human cancers, including breast cancer. An important signaling pathway …

Microemulsion for prolonged release of fenretinide in the mammary tissue and prevention of breast cancer development

GC Salata, ID Malago… - Molecular …, 2021 - ACS Publications
The need of pharmacological strategies to preclude breast cancer development motivated
us to develop a non-aqueous microemulsion (ME) capable of forming a depot after …

Triazine-modified dendrimer for efficient TRAIL gene therapy in osteosarcoma

Y Wang, L Li, N Shao, Z Hu, H Chen, L Xu, C Wang… - Acta biomaterialia, 2015 - Elsevier
Osteosarcoma is a high-grade malignant bone tumor that usually develops in the teenagers.
Despite improvement in therapy, the five-year survival rate is poor for patients not …

Cold physical plasma-mediated fenretinide prodrug activation confers additive cytotoxicity in epithelial cells

M Ahmadi, D Singer, F Potlitz, Z Nasri, T von Woedtke… - Antioxidants, 2023 - mdpi.com
Cold physical plasma is a partially ionized gas operated at body temperature and utilized for
heat-sensitive technical and medical purposes. Physical plasma is a multi-component …

Fenretinide induces apoptosis and synergises the apoptosis inducing effect of gemcitabine through inhibition of key signalling molecules involved in A549 cell survival …

HA Al-Bustany, HA Muhammad, MA Chawsheen… - Cellular …, 2023 - Elsevier
Fenretinide is a synthetic retinoid compound, which induces apoptosis via generating
reactive oxygen species (ROS) and modulating PI3K/Akt/mTOR signalling pathway. We …

Fenretinide (4-HPR) targets caspase-9, ERK 1/2 and the Wnt3a/β-catenin pathway in medulloblastoma cells and medulloblastoma cell spheroids

B Bassani, D Bartolini, A Pagani, E Principi, M Zollo… - PLoS …, 2016 - journals.plos.org
Medulloblastoma (MB), a neuroectodermal tumor arising in the cerebellum, represents the
most frequent childhood brain malignancy. Current treatments for MB combine radiation and …

A Lipid-based in situ-forming hexagonal phase for prolonged retention and drug release in the breast tissue

GC Salata, ID Malagó, LB Lopes - AAPS PharmSciTech, 2022 - Springer
In this study, the addition of monoolein to phosphatidylcholine (PC), tricaprylin, and
propylene glycol (PG) mixtures was studied to produce fluid precursor formulations (FIPs) …

[HTML][HTML] A novel 1, 4-naphthoquinone-derived compound induces apoptotic cell death in breast cancer cells

D Karakaş, RO Akar, Z Gökmen, NG Deniz… - Turkish Journal of …, 2019 - ncbi.nlm.nih.gov
Breast cancer is the most-diagnosed cancer type among women. The triple-negative
subtype is an especially aggressive type of breast cancer. Although chemotherapy is almost …

Iron (II)− Polypyridyl Complexes Inhibit the Growth of Glioblastoma Tumor and Enhance TRAIL‐Induced Cell Apoptosis

H Lin, Y Wang, H Lai, X Li… - Chemistry–An Asian …, 2018 - Wiley Online Library
A promising cancer‐targeting agent for the induction of apoptosis in tumor necrosis factor
(TNF) proteins, the TNF‐related apoptosis‐inducing ligand (TRAIL) ligand, has found limited …

The M30 assay does not detect apoptosis in epithelial-derived cancer cells expressing low levels of cytokeratin 18

B Cevatemre, E Ulukaya, M Sarimahmut, AY Oral… - Tumor Biology, 2015 - Springer
The primary aim of this study was to compare measurement of apoptosis by M30
immunoreactivity (a biomarker for apoptosis) to other apoptosis assays (morphological …