Cancer remains the second leading cause of mortality worldwide. In the course of this
multistage and multifactorial disease, a set of alterations takes place, with genetic and …

There is substantial evidence that sphingosine 1-phosphate (S1P) is involved in cancer.
S1P regulates processes such as inflammation, which can drive tumorigenesis; …

The complex interactions of cells with extracellular matrix (ECM) play crucial roles in
mediating and regulating many processes, including cell adhesion, migration, and signaling …

G protein-coupled receptors (GPCRs) constitute the largest and most diverse protein family
in the human genome with over 800 members identified to date. They play critical roles in …

Tissue invasion during metastasis requires cancer cells to negotiate a stromal environment
dominated by cross-linked networks of type I collagen. Although cancer cells are known to …

Interactions between cells and the extracellular matrix are at the core of tissue engineering
and biology. However, most studies of these interactions have used traditional two …

The potent pleiotropic lipid mediator sphingosine-1-phosphate (S1P) participates in
numerous cellular processes, including angiogenesis and cell survival, proliferation, and …

Objective: We sought to identify and investigate the functional role of the major endothelial
cell (EC)-derived factors that control pericyte recruitment to EC tubes and pericyte-induced …

Cancer cells can move through tissues in a variety of different ways. In some cases, an
epithelial-to-mesenchymal transition enables cancer cells to acquire fibroblast-like migratory …

Cell migration and invasion is a key driving factor for providing essential cellular functions
under physiological conditions or the malignant progression of tumors following downward …