[HTML][HTML] Selective autophagy of intracellular organelles: recent research advances
Macroautophagy (hereafter called autophagy) is a highly conserved physiological process
that degrades over-abundant or damaged organelles, large protein aggregates and …
that degrades over-abundant or damaged organelles, large protein aggregates and …
Autophagy in Parkinson's disease
Impaired protein homeostasis and accumulation of damaged or abnormally modified protein
are common disease mechanisms in many neurodegenerative disorders, including …
are common disease mechanisms in many neurodegenerative disorders, including …
A new pathway for mitochondrial quality control: mitochondrial‐derived vesicles
The last decade has been marked by tremendous progress in our understanding of the cell
biology of mitochondria, with the identification of molecules and mechanisms that regulate …
biology of mitochondria, with the identification of molecules and mechanisms that regulate …
Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65
A Kazlauskaite, C Kondapalli, R Gourlay… - Biochemical …, 2014 - portlandpress.com
We have previously reported that the Parkinson's disease-associated kinase PINK1 (PTEN-
induced putative kinase 1) is activated by mitochondrial depolarization and stimulates the …
induced putative kinase 1) is activated by mitochondrial depolarization and stimulates the …
Parkin and PINK 1 function in a vesicular trafficking pathway regulating mitochondrial quality control
GL McLelland, V Soubannier, CX Chen… - The EMBO …, 2014 - embopress.org
Mitochondrial dysfunction has long been associated with P arkinson's disease (PD). Parkin
and PINK 1, two genes associated with familial PD, have been implicated in the degradation …
and PINK 1, two genes associated with familial PD, have been implicated in the degradation …
PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65
C Kondapalli, A Kazlauskaite, N Zhang… - Open …, 2012 - royalsocietypublishing.org
Missense mutations in PTEN-induced kinase 1 (PINK1) cause autosomal-recessive
inherited Parkinson's disease (PD). We have exploited our recent discovery that …
inherited Parkinson's disease (PD). We have exploited our recent discovery that …
Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment
AW Greene, K Grenier, MA Aguileta, S Muise… - EMBO …, 2012 - embopress.org
Mutations in phosphatase and tensin homologue‐induced kinase 1 (PINK1) cause
recessively inherited Parkinson's disease (PD), a neurodegenerative disorder linked to …
recessively inherited Parkinson's disease (PD), a neurodegenerative disorder linked to …
Structure of parkin reveals mechanisms for ubiquitin ligase activation
Mutations in the PARK2 (parkin) gene are responsible for an autosomal recessive form of
Parkinson's disease. The parkin protein is a RING-in-between-RING E3 ubiquitin ligase that …
Parkinson's disease. The parkin protein is a RING-in-between-RING E3 ubiquitin ligase that …
USP 8 regulates mitophagy by removing K 6‐linked ubiquitin conjugates from parkin
Mutations in the Park2 gene, encoding the E3 ubiquitin‐ligase parkin, are responsible for a
familial form of Parkinson's disease (PD). Parkin‐mediated ubiquitination is critical for the …
familial form of Parkinson's disease (PD). Parkin‐mediated ubiquitination is critical for the …
PINK1/Parkin Mediated Mitophagy, Ca2+ Signalling, and ER–Mitochondria Contacts in Parkinson's Disease
Endoplasmic reticulum (ER)–mitochondria contact sites are critical structures for cellular
function. They are implicated in a plethora of cellular processes, including Ca2+ signalling …
function. They are implicated in a plethora of cellular processes, including Ca2+ signalling …