Long COVID endotheliopathy: hypothesized mechanisms and potential therapeutic approaches

J Ahamed, J Laurence - The Journal of clinical investigation, 2022 - Am Soc Clin Investig
SARS-CoV-2–infected individuals may suffer a multi–organ system disorder known as “long
COVID” or post-acute sequelae of SARS-CoV-2 infection (PASC). There are no standard …

The pathogenesis of coronavirus-19 disease

AC Borczuk, RK Yantiss - Journal of biomedical science, 2022 - Springer
Severe acute respiratory syndrome-associated coronavirus-2 (SARS-CoV-2) is the causal
agent of coronavirus disease-2019 (COVID-19), a systemic illness characterized by variably …

Long-term effect of SARS-CoV-2 infection on cardiovascular outcomes and all-cause mortality

A Aleksova, AL Fluca, G Gagno, A Pierri, L Padoan… - Life sciences, 2022 - Elsevier
Since the very beginning of the coronavirus disease 2019 (COVID-19) pandemic in early
2020, it was evident that patients with cardiovascular disease (CVD) were at an increased …

Neutrophils predominate the immune signature of cerebral thrombi in COVID-19 stroke patients

A Genchi, A Semerano, G Schwarz… - Acta Neuropathologica …, 2022 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is associated with an increased risk of
thrombotic events. Ischemic stroke in COVID-19 patients entails high severity and mortality …

Status of major hemostatic components in the setting of COVID-19: the effect on endothelium, platelets, coagulation factors, fibrinolytic system, and complement

M Sayyadi, S Hassani, M Shams, A Dorgalaleh - Annals of Hematology, 2023 - Springer
The coagulation, fibrinolytic, anticoagulation, and complement systems are in delicate
balance with the vessel wall endothelium ensuring appropriate hemostasis. Coagulopathy …

Pathophysiology of COVID-19: critical role of hemostasis

SA Andrade, DA de Souza, AL Torres… - Frontiers in cellular …, 2022 - frontiersin.org
The COVID-19 pandemic, caused by SARS-CoV-2, had its first cases identified in late 2019
and was considered a clinical pandemic in March 2020. In March 2022, more than 500 …

The pathological maelstrom of COVID-19 and cardiovascular disease

M Giacca, AM Shah - Nature Cardiovascular Research, 2022 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) is a consequence of infection of the upper
and lower respiratory tract with severe acute respiratory syndrome coronavirus 2 but often …

[PDF][PDF] Geroscience and pathology: a new frontier in understanding age-related diseases

M Fekete, D Major, A Feher… - Pathology and …, 2024 - por-journal.com
Geroscience, an emerging discipline at the intersection of aging and disease, seeks to
understand the relationship between the aging process and pathogenesis of age-related …

Platelet-neutrophil interaction in COVID-19 and vaccine-induced thrombotic thrombocytopenia

J Hirsch, G Uzun, J Zlamal, A Singh… - Frontiers in …, 2023 - frontiersin.org
Coronavirus disease 2019 (COVID-19) is known to commonly induce a thrombotic diathesis,
particularly in severely affected individuals. So far, this COVID-19-associated coagulopathy …

The role of NETosis in heart failure

S Kostin, F Krizanic, T Kelesidis, N Pagonas - Heart Failure Reviews, 2024 - Springer
The hallmark of heart failure (HF) is structural myocardial remodeling including
cardiomyocyte hypertrophy, fibrosis, cardiomyocyte cell death, and a low-grade aseptic …