Approximately half of the patients with signs and symptoms of heart failure have a left
ventricular ejection fraction that is not markedly abnormal. Despite the historically initial …

Approximately half of all patients with heart failure (HF) have a preserved ejection fraction,
and the prevalence is growing rapidly given the aging population in many countries and the …

Over the past decade, myocardial structure, cardiomyocyte function, and intramyocardial
signaling were shown to be specifically altered in heart failure with preserved ejection …

Background—Prominent features of myocardial remodeling in heart failure with preserved
ejection fraction (HFPEF) are high cardiomyocyte resting tension (Fpassive) and …

The heart must continuously pump blood to supply the body with oxygen and nutrients. To
maintain the high energy consumption required by this role, the heart is equipped with …

Heart failure with preserved ejection fraction (HFpEF) involves multiple pathophysiological
mechanisms, which result in the heterogeneous phenotypes that are evident clinically, and …

In mammals, aging is associated with accumulation of senescent cells. Stresses such as
telomere shortening and reactive oxygen species induce “cellular senescence”, which is …

Background—Obesity and diabetes mellitus are independently associated with the
development of heart failure. In this study, we determined the respective effects of obesity …

Normal cardiac function requires that intracellular Ca2+ concentration be reduced to low
levels in diastole so that the ventricle can relax and refill with blood. Heart failure is often …

Background Whereas heart failure with reduced ejection fraction (HFrEF) is associated with
ventricular dilation and markedly reduced systolic function, heart failure with preserved …