Skin injuries and chronic non-healing wounds are one of the major global burdens on the
healthcare systems worldwide due to their difficult-to-treat nature, associated co-morbidities …

The Baculovirus Expression Vector System (BEVS), a mature foreign protein expression
platform, has been available for decades, and has been effectively used in vaccine …

Long noncoding RNAs (lncRNAs) are emerging as important regulators of numerous
biological processes, especially in cancer development. Aberrantly expressed and …

Highlights•Inducible gene regulation has been a critical tool in interrogating biological
systems.•Small-molecule induction enables regulation at the DNA, RNA, and protein …

The long non-coding RNAs (lncRNAs) constitute an important class of the human
transcriptome. The discovery of lncRNAs provided one of many unexpected results of the …

RNAi effectors (eg siRNA, shRNA and miRNA) can trigger the silencing of specific genes
causing alteration of genomic functions becoming a new therapeutic area for the treatment …

Traumatic optic neuropathy or other neurodegenerative diseases, including optic nerve
transection, glaucoma, and diabetic retinopathy, can lead to progressive and irreversible …

Purpose: Mutations in the retinal transcription factor cone-rod homeobox (CRX) gene result
in severe dominant retinopathies. A large animal model, the Rdy cat, carrying a …

Conditionally replicating adenoviruses (CRAds), or known as replication-selective
adenoviruses, were discovered as oncolytic gene vectors several years ago. They have a …

Preventing the replication of adenovirus could have practical uses, such as controlling
infection with wild-type virus or in applications involving recombinant vectors. Mainly …