HLA imputation and its application to genetic and molecular fine-mapping of the MHC region in autoimmune diseases
Variations of human leukocyte antigen (HLA) genes in the major histocompatibility complex
region (MHC) significantly affect the risk of various diseases, especially autoimmune …
region (MHC) significantly affect the risk of various diseases, especially autoimmune …
[HTML][HTML] Autoantigen-specific CD4+ T cells acquire an exhausted phenotype and persist in human antigen-specific autoimmune diseases
C Saggau, P Bacher, D Esser, M Rasa, S Meise… - Immunity, 2024 - cell.com
Pro-inflammatory autoantigen-specific CD4+ T helper (auto-Th) cells are central
orchestrators of autoimmune diseases (AIDs). We aimed to characterize these cells in …
orchestrators of autoimmune diseases (AIDs). We aimed to characterize these cells in …
A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response
Fine-mapping to plausible causal variation may be more effective in multi-ancestry cohorts,
particularly in the MHC, which has population-specific structure. To enable such studies, we …
particularly in the MHC, which has population-specific structure. To enable such studies, we …
Detailed stratified GWAS analysis for severe COVID-19 in four European populations
F Degenhardt, D Ellinghaus, S Juzenas… - Human molecular …, 2022 - academic.oup.com
Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a
deeper analysis of the host genetic contribution to severe COVID-19 is important to improve …
deeper analysis of the host genetic contribution to severe COVID-19 is important to improve …
The polymorphism of HLA‐A,‐C,‐B,‐DRB3/4/5,‐DRB1,‐DQB1 loci in Zhejiang Han population, China using NGS technology
F Wang, L Dong, W Wang, N Chen… - International Journal …, 2021 - Wiley Online Library
The distributions of HLA allele and haplotype are various in the populations. Currently, the
data for HLA alleles and haplotypes at three fields resolution level in Chinese Han …
data for HLA alleles and haplotypes at three fields resolution level in Chinese Han …
A novel unconventional T cell population enriched in Crohn's disease
Objective One of the current hypotheses to explain the proinflammatory immune response in
IBD is a dysregulated T cell reaction to yet unknown intestinal antigens. As such, it may be …
IBD is a dysregulated T cell reaction to yet unknown intestinal antigens. As such, it may be …
Tutorial: a statistical genetics guide to identifying HLA alleles driving complex disease
The human leukocyte antigen (HLA) locus is associated with more complex diseases than
any other locus in the human genome. In many diseases, HLA explains more heritability …
any other locus in the human genome. In many diseases, HLA explains more heritability …
How genetic risk contributes to autoimmune liver disease
D Ellinghaus - Seminars in immunopathology, 2022 - Springer
Genome-wide association studies (GWAS) for autoimmune hepatitis (AIH) and
GWAS/genome-wide meta-analyses (GWMA) for primary biliary cholangitis (PBC) and …
GWAS/genome-wide meta-analyses (GWMA) for primary biliary cholangitis (PBC) and …
The landscape of host genetic factors involved in immune response to common viral infections
Background Humans and viruses have co-evolved for millennia resulting in a complex host
genetic architecture. Understanding the genetic mechanisms of immune response to viral …
genetic architecture. Understanding the genetic mechanisms of immune response to viral …