C3 is the central effector molecule of the complement system, mediating its multiple
functions through different binding sites and their corresponding receptors. We will introduce …

Damage associated molecular patterns (DAMPs) are endogenous molecules originate from
damaged cells and tissues with the ability to trigger and/or modify innate immune responses …

Sickle cell disease (SCD) is the most common hereditary disorder of hemoglobin (Hb),
which affects approximately a million people worldwide. It is characterized by a single …

Sickle cell disease (SCD) is an inherited hemoglobinopathy that is caused by the presence
of abnormal hemoglobin S (HbS) in red blood cells, leading to alterations in red cell …

The complement system is part of the innate immunity. An increased activation or a loss of
the regulation of this fine‐tuned cascade is involved in a variety of hematological diseases …

Patients with sickle cell disease (SCD) have ongoing hemolysis that promotes endothelial
injury, complement activation, inflammation, vaso-occlusion, ischemia-reperfusion …

The genetic and molecular basis of sickle cell disease (SCD) has long been characterized
but the pathophysiological basis has not been entirely defined. How a red cell hemolytic …

Sickle cell disease (SCD) is an inherited disorder, which occurs due to a single gene
mutation. It has multisystemic manifestations, affecting millions of people worldwide. The …

Sickle cell disease (SCD) is a common inherited clinical syndrome, characterized by the
presence of hemoglobin S. Anemia, susceptibility to infections and episodes of vaso …

Fifty years ago, people with sickle cell disease (SCD) were discouraged from becoming
pregnant, but now, most should be supported if they choose to pursue a pregnancy. They …