Fungi must meet four criteria to infect humans: growth at human body temperatures,
circumvention or penetration of surface barriers, lysis and absorption of tissue, and …

The zebrafish has become a widely accepted model host for studies of infectious disease,
including fungal infections. The species is genetically tractable, and the larvae are …

Platinum-based drugs are the firstline of treatment for non-small cell lung cancer (NSCLC),
but resistance to these drugs is a major obstacle to effective chemotherapy. Our previous …

Plant pathogens are challenged by host-derived iron starvation or excess during infection,
but the mechanism through which pathogens counteract iron stress is unclear. Here, we …

The Fenton-chemistry-generating properties of copper ions are considered a potent
phagolysosome defense against pathogenic microbes, yet our understanding of underlying …

Here, we investigated which stress responses were influenced by the MpkC and SakA
mitogen‐activated protein kinases of the high‐osmolarity glycerol (HOG) pathway in the …

Among neurogenerative diseases, amyotrophic lateral sclerosis (ALS) is a fatal illness
characterized by a progressive motor neuron dysfunction in the motor cortex, brainstem and …

Fungal infections are responsible for millions of human deaths annually. Copper, an
essential but toxic trace element, plays an important role at the host-pathogen axis during …

Copper homeostasis is important for virulence of the fungus Cryptococcus neoformans,
which can cause lethal meningoencephalitis in humans. Cryptococcus cells encounter high …

Cryptococcus neoformans-mediated meningoencephalitis is a critical infectious disorder of
the human central nervous system. However, efficient treatment for the disease is limited …